128 



STUDIES ON PATHOLOGIC OVA. 



No. 189. 



(1) T. E. Oertel, Augusta, Georgia. 



(2) A 28X25X15 mm.; B 4 mm. 



(4) The ovum filled with granular and reticular magma, 

 contains a deformed embryo lying within a distended 

 amnion, 8 mm. in diameter. 



(5) The umbilical vesicle and amnion appear to be 

 normal for an embryo of this size, but the body is greatly 

 deformed, the central nervous system is open throughout 

 its extent and partly encircles the dwarfed embryo like a 

 broad hoop around a ball. A number of the motor roots 

 of the spinal nerves are developed, more in the region ot 

 the tail than elsewhere. There are no cranial nerves. The 

 heart is a vesicle filled with blood, hanging into the ccelom 

 and slightly attached to the body-wall. Its vascular con- 

 nection with the body is entirely cut off. The blood- 

 vessels of the body are irregular in shape and entirely 

 changed from the normal type. 1 hey are filled with 

 blood which extends through their walls into the sur- 

 rounding tissues. The branchial arches correspond to 

 an embryo of this size. There are still traces of optic 

 vesicles, chorda, and possibly allantois, the liver, stomach, 

 and intestines having degenerated. 



No. 198. 



(1) R. E. Larsen, Chicago, Illinois. 



(2) A 25X25X25 mm. 



(4) The interior is filled with considerable reticular, 

 and large clumps of granular magma. Embedded in this 

 is a large cylindrical pedicle, 7 mm. long, bent upon 

 itself. Sections of the specimen show the pedicle to be 

 the umbilical cord rounded off at its former juncture 

 with the embryo. 



(5) The mesoderm of the cord, thickened cnorion, 

 and villi is fibrous, having also an excess of spindle- 

 shaped cells. The blood-vessels are all very large, those 

 of the villi as well as most of those of the main wall being 

 gorged with blood. The large blood-vessels of the cord 

 are empty. Within the cavity of the amnion, scattered 

 throughout the magma, are numerous flakes of tissue of 

 the embryo and a great many free cells. 



No. 244. 



(1) M. Brodel, Baltimore, Maryland. (From Dr. 

 Kelly's sanitarium.) 



(2) B 4 mm. 



(4) The specimen is inclosed in the amnion, which 

 measures 25X15X15 mm., and is surrounded by a 

 mass of granular magma. 



(5) The sections show the amnion attached along most 

 of the ventral side of the embryo, somewhat as it is in 

 the normal specimen at the end of the second week. The 

 central nervous system is still quite sharply defined, 

 being more characteristic in the head than in the trunk. 

 The heart is composed of a solid mass of cells in the front 

 of the embryo, and extends as a horn-like process to the 

 head. Between the heart and the body there is a large 

 group of epithelial cells, in which are scattered some 

 small round cells, probably the remnant of the liver. 

 Otherwise the tissue of the embryo is of even structure, 

 with an occasional necrotic area. Most of the epidermis 

 is missing. Neither umbilical cord nor umbilical vesicle is 

 present, the free embryo being attached to the amnion only. 



No. 247. 



(1) W. S. Seymour, Trappe, Maryland. 



(2) A 40X40X17 mm.; B 2.5 mm. 



(4) The ovum was found filled with granular magma, 

 and in the center, far away from the chorion, there is a 

 free body. 



(5) Sections of the chorion show that it is slightly 

 macerated, and that the stroma of the villi has undergone 

 hydatiform degeneration. The villi are without capillaries 

 and the amnion is missing. At points between the villi the 

 trophoblast cells form mounds below the epithelium, 



which have a tendency to penetrate the mesoderm of the 

 chorion. The pear-shaped body is probably the embryo. 

 It contains cavities lined with epithelium and surrounded 

 by a considerable amount of mesoderm which contains 

 numerous blood-vessels filled with blood. There are some 

 accessory vesicles in this layer similar to those found in 

 No. 78, described above. 

 (6) Hydatiform degeneration. 



No. 253. 



(1) M. Brodel, Baltimore, Maryland. 



(2) A 35X30X15 mm.; B 4 mm. 



(5) Chorion and villi are somewhat hyaline, with only 

 indications of blood-vessels within them. The amnion, 

 which measures 19X13X13 mm., is attached at one 

 point, has hyaline walls, and does not contain the embryo. 

 The latter is a swollen infiltrated specimen of the third 

 week, with no brain and little of its spinal cord left. The 

 rest of the structures (heart, ccelom, and Wolffian body) 

 are quite sharply defined, but are well infiltrated with 

 round cells. Most of the epidermis is intact. The arm- 

 buds are well denned. 



No. 264. 



(1) Wm. S. Gardner, Baltimore, Maryland. 



(2) A 25X20X15 mm.; B 2 mm. 



(3) Last period occurred August 12, but menses had 

 been irregular for three months before. 



(5) The ccelom is filled with a hard hyaline magma, 

 rich in round cells, in which is embedded the umbilical 

 vesicle, measuring 2.5 mm. in diameter. The chorion is 

 thickened, fibrous, and covered with some villi. These 

 also are fibrous and most of them are non-vascular. 



(6) Decidua infiltrated. 



No. 275. 



(1) W. Tobie, Portland, Maine. 



(2) A 40X30X25 mm.; B 8 mm. (straightened). 



(4) The chorion of this specimen, which was thought to 

 be 2 months old, is thin and covered with some villi 

 embedded in much blood. In structure it is fibrous, with 

 a diminished amount of epithelium, and contains no 

 blood-vessels. Within is an amniotic cavity, filled with a 

 clear fluid, into which the deformed embryo projects. The 

 exoccelom is from 2 to 3 mm. wide and is filled with typical 

 magma reticule. 



(5) The structures of the embryo form almost a con- 

 tinuous mass of tissues, in which the irregular central 

 nervous system can still be outlined. Most of the epider- 

 mis is still intact. The lenses of the eyes form small 

 pearls inclosed in capsules lying beneath the skin. In 

 front of them are two small bodies connected with the 

 epidermis, which might pass for lenses, but which are prob- 

 ably olfactory pits. In a number of places the tissues are 

 fibrous. The decidua shows some infiltration and the 

 villi are decidedly fibrous, non-vascular, and glued. 



(6) Mild infiltration. 



No. 291. 



(1) A. Wegefarth, Baltimore, Maryland. (Brodel col- 

 lection.) 



(2) B 5 mm. 



(4) The membranes are devoid of villi and very thin. 

 The umbilicial vesicle is necrotic and filled with an irregu- 

 lar mass. 



(5) Sagittal sections of the embryo show that the speci- 

 men is pathological, its head being rounded and the 

 epidermis haying fallen off. The spinal cord is distended 

 and the brain is solid. Veins and arteries are greatly 

 distended with blood. The eye-vesicles are atrophic and 

 the lenses dissociated, but encircled by a sharply de- 

 fined capsule 



No. 292a. 



(1) J. P. West, Bellaire, Ohio. 



(2) A 50X30X30 mm.; B 3.5 mm. 



