130 



STUDIES ON PATHOLOGIC OVA. 



(4) The ovum is well covered with villi which are normal 

 in form. Within there is a large quantity of reticular 

 magma encircling several nodules, one of which appears 

 to be the embryo. This is inclosed with its amnion and 

 measures 3 mm. in length. 



(5) The villi are non-vascular, have undergone mueoid 

 degeneration, and are stuck together by a very pronounced 

 mueoid mass, within which radiate numerous syncytial 

 cells. At certain points these are covered with maternal 

 blood; otherwise there is no indication of inflammatory 

 changes. The form of the embryo and amnion appear to 

 be quite normal, but the former is markedly dissociated. 

 Its blood-vessels, including those of the chorion, are gorged 

 with embryonic blood. The dissociation is so marked that 

 practically all of the organs are involved and more or less 

 obliterated, although their main form can still be made 

 out. The lumen of the brain and cord are mostly filled 

 with cells, which also invade the otic vesicle. The process 

 of dissociation has involved the eye-vesicles to such an 

 extent that they are entirely obliterated. At this point the 

 cells of the brain seem to shade over to the mesenchyme 

 of the head without any line of demarcation. 



(6) Decidua absent. Probable hydatiform degeneration. 



No. 436. 



(1) J. Park West, Bellaire, Ohio. 



(2) A 65X40X30 mm.; B 2.9 mm. long. 



(3) "Patient a Russian Jewess, 31 years old, who has 

 four children, the youngest 18 months old. In July 1907 

 she aborted at 2 months; in January 1908 at 3 months; 

 this specimen May 17, 1908, at 2 months. She appears to 

 be healthy and shows no evidence of syphilis." 



(4) The large fleshy ovum is partly covered by deeidua 

 with atrophic villi. Its wall is thin, and when opened it 

 was found to contain dense reticular and granular magma. 

 On one side is a small nodule about 2.9 mm. in diameter, 

 which encircles an atrophic embryo. The gross appear- 

 ance of the embryonic mass looks much like a fish embryo. 

 The yolk-sac is distended, has thickened walls, and is 

 attached to the chorion by means of a pronounced stalk. 

 The embryo lies spread upon this vesicle with head and 

 tail ends protruding somewhat. 



(5) Sections of the chorion show that both the chorionic 

 membrane and some villi are fibrous and stuck together 

 by a large quantity of mueoid tissue, within which are 

 numerous buds of syncytium. The chorionic membrane 

 is very vascular, but few vessels are found within the villi. 

 Sections of the embryonic mass show that the vesicle is 

 directly continuous with the body-wall; that is, the body 

 is distended sufficiently to incorporate entirely the umbili- 

 cal vesicle. The body-wall is very fibrous and there are 

 several bundles of these fibers which push up the epithelium 

 into papilla?. The central nervous system is more or less 

 dissociated, but can be followed throughout most of the 

 length of the embryo, and occasionally a lumen is present. 

 Its course is interrupted at several points. In the head 

 end there is an additional body, which may represent the 

 pharynx, and which does not communicate with the yolk- 

 sac, but appears to be continuous with the brain-tube; it 

 may possibly belong to the latter. In the ventral midline 

 there is a large single blood-vessel which represents all that 

 is left of the heart. From this other blood-vessels are 

 radiating into the body of the embryo. In the tail end of 

 the embryo the neural tube has a very pronounced lumen, 

 apparently filled with cells. In this region the amnion is 

 continuous with the lateral sides of the vesicle, showing 

 the line of demarcation between the body of the embryo 

 and the yolk-sac. The chorda, eye and ear vesicles are 

 absent. The deeidua is somewhat infiltrated, fibrous and 

 degenerate. 



(6) Decidua slightly infiltrated. 



No. 440. 



(1) W. Preston Miller, Hagerstown, Maryland. 



(2) A 25X20X15 mm.; B 2.5 mm. 



(4) The chorion, which appears to be normal, is covered 

 entirely with villi. When opened it is found to contain a 

 great quantity of reticular magma, within which is buried 

 an embryo 2.5 mm. long. 



(5) The amnion is greatly distended, showing a marked 

 hydramnios. Sections of the embryo show that it has 

 undergone extensive dissociation, the central nervous 

 system being the only structure that can be made out. 

 Most of it is solid, cells from the wall having completely 

 filled its lumen. In the anterior end of the embryo the 

 eye and ear vesicles can still be outlined, although they 

 are mostly filled with round cells. The chorionic wall and 

 its villi have undergone fibrous degeneration, and few 

 blood-vessels are present. 



(6) Hydatiform degeneration. Decidua absent. 



No. 441. 



(1) J. T. Haller, Davenport, Iowa. 



(2) A 17X13X10 mm.; B 2.3mm. 



(4) A transparent sac, about the size of the ovum, pro- 

 trudes therefrom, and is no doubt the amnion. The ovum 

 contains some granules, and near the attachment of the 

 sac to the chorion there is an embryo, 2.3 mm. long, which 

 is somewhat curled upon itself. Within the chorion 

 there is considerable magma. The hydramnios is very 

 conspicuous. 



(5) Sections of the chorion show that its wall is some- 

 what fibrous, as is also the mesenchyme of the villi. Con- 

 siderable trophoblast is attached to the tips of the villi, 

 and between them there is a great deal of fibrinous 

 substance intermingled with many leucocytes. Into this 

 substance large buds of syncytium ramify. The tissues 

 of the embryo are greatly dissociated, the central nervous 

 system being composed of a uniform layer of round cells. 

 The spinal cord does not reach to the tail end of the em- 

 bryo, and the eye and ear vesicles are destroyed. Near 

 the attachment of the embryo to the amnion there is a 

 grouping of small round cells which no doubt represent the 

 heart. In certain places these cells stream into the ecelom, 

 which can barely be outlined. The umbilical vesicle is 

 small and atrophic and attached to the lower part of the 

 embryo. 



(6) Hydatiform degeneration. Decidua absent. 



No. 504. 



(1) H. I. Davenport, Auburn, New York. 



(2) A 15X15X15 mm.; B 0.2 mm. long. 



(3) Patient 40 years of age; youngest child aged 6 

 months. Woman menstruated a little about February 3 

 and missed the next period, which should have come on 

 about March 3. On March 17 passed some blood, accom- 

 panied by slight pain in back and over symphysis pubis. 

 The abortion followed the next day. 



(5) The entire specimen was cut into serial sections, and 

 in several of these the remnant of a nodular embryo, about 

 0.2 mm. in diameter, was found. The embryo lies isolated 

 within the extensive magma and contains two cavities. It 

 is markedly macerated. In the region of the nodule there 

 are numerous delicate mesodermal processes from the 

 chorion, pointing towards it and indicating the point of 

 its former attachement. There also seem to be a few blood- 

 vessels in the chorionic wall and in some of the villi. The 

 villi are capped with considerable trophoblast, most of 

 which is atrophic and macerated. There are also numer- 

 ous buds of syncytium arising directly from the chorionic 

 membrane. 



No. 525. 



(1) David Jurist, New York. 



(2) A 50X35X25 mm.; B 3 mm. long. 



(4) The somewhat solid mole contains a clear vesicle 

 25 mm. in diameter. Its inner surface is smooth, but 

 within the vesicle, which proves to be the amnion, there is 

 considerable granular matter, and attached to one side 

 is a nodular embryo 3 mm. long. On one side of the 

 chorion is a small tuft of villi. Sections of the chorion 



