134 



STUDIES ON PATHOLOGIC OVA. 



on one side is a small spherical body, without the charac- 

 teristic form of a degenerate embryo. Further gross 

 examination was impossible without injuring the specimen. 



(5) The villi and chorion are very fibrous, and some of 

 the mesenchyme is edematous with large cavities. The 

 trophoblast is quite irregular in shape. There are some 

 buds of syncytium and strands of a mucus-like substance. 

 There are many Hofbauer cells in the tissues. The amnion 



is fibrous and attached to the chorion by means of a short 

 cord. The embryo, which is closely surrounded by the 

 amnion, is turned away from this cord, and on the side 

 opposite the amnion there is an opening through which 

 the tail of the embryo protrudes to reach out to and enter 

 the very small atrophic umbilical vesicle. The back of 

 the embryo is toward the umbilical cord and adjacent 

 chorion. The tissues of the embryo are almost completely 

 dissociated. The heart can still be outlined, as also a few 

 of the body nerves. The central nervous system forms a 

 large tube mostly filled with cells, reaching through the 

 body up into the head, where it is practically lost. In the 

 forepart of the head is a sharply defined, epithelial pocket, 

 which may represent the beginning of a lens. 



(6) Early hydatiform degeneration. Decidua absent. 



No. 708. 



(1) N. I. Ardan, Bristol, Tennessee-Virginia. 



(2) A 70X60X40 mm.; B 2 mm. 



(3) The specimen came from the first tubal pregnancy 

 of a woman 24 years of age. Dizziness began two weeks 

 before the abortion and continued with hemorrhage. 



(4) The specimen measures 70X60X40 mm. and is 

 covered with villi which are very markedly developed, 

 in fact, hypertrophic. It contains a cavity lined with 

 smooth membrane. This cavity measures 45X20 mm., 

 and from it protrudes a small umbilical cord, 10 mm. long 

 and 2 mm in diameter. At the end of the cord there is a 

 small opaque knob, a little less than 2 mm. in diameter, 

 undoubtedly a remnant of the embryo. 



(5) The specimen consists of a fibrous chorionic mem- 

 brane, to which are attached numerous long, irregular 

 villi, and beyond these large areas of inflamed decidua, the 

 inflammatory processes often being so extensive as to 

 produce small abscesses. The villi are matted together 

 with fibrinoid substance, a great deal of blood, and fibrin. 

 The trophoblast is scanty. The mesenchyme of the villi 

 contains no blood-vessels. The amnion is closely adherent 

 to the chorion. The embryo is represented by a small 

 nodule of largely undifferentiated tissue. 



(6) Marked infiltration; hydatiform degeneration. 



No. 712. 



(1) G. W. Cox, Hartford, Connecticut. 



(2) A 30X30X30 mm.; B 2 mm. long. 



(3) Patient aged 37 years, married, and the mother of 

 a child 2 years old. No other pregnancies. Health good, 

 except recently a neoplasm of the breast. Periods about 

 regular and normal. No history of venereal infection. 

 Last period March 21; 36 hours after operation vaginal 

 hemorrhage started. This increased in severity and pa- 

 tient was packed 24 hours later. Twelve hours after 

 being packed she entered the hospital (June 4), and since 

 hemorrhage had stopped she was curetted. The specimen 

 was procured at this time. 



(4) The chorion is covered entirely with long, ragged 

 villi, except at one end. Without the stem, which forms 

 this end, the specimen measures 30X30X30 mm. The 

 amnion is greatly folded. This cavity contains a trans- 

 parent body 8 mm. long and nearly 2 mm. in diameter 

 the umbilical cord. 



(5) The chorionie wall, amnion, and villi are fibrous. 

 The trophoblast is quite active, producing numerous buds 

 of syncytium and clumps of trophoblast which have 

 partially undergone fibrinoid degeneration. The body 

 within the chorion consists mostly of an umbilical cord, 

 which is capped by a clump of uniform round cells, which 

 no doubt represent the embryo. A highly differentiated 



group of these cells encircles a cavity in the center, and 

 possibly represents the heart. No other structures can 

 be made out. 



No. 714. 



(1) G. J. Lochboeler, Washington, District of Columbia. 



(2) A 30X20X20 mm.; B 2 mm. long. 



(3) Patient aged 38 years, married at 26 years. Eight 

 pregnancies; five normal, one following 18 months after 

 ovarectomy for cystic disease; since then one miscarriage 

 at V/i months (macerated fetus), one at 2^ months, and 

 another (the last) at 2 months. All occurred without 

 assignable cause. Last period April 20 to 25; abortion 

 June 25. Was infected at the time of abortion from 

 inflammation of stump of right tube, which had been 

 removed five years previously with a cystic ovary. Fam- 

 ily fertile. 



(4) The chorion measures 30X20X20 mm., and is 

 covered with long, delicate villi. It contains a cavity 15 

 mm. in diameter and lined by an amniotic membrane. 

 In the bottom are several small nodules, one of which is 

 pointed and protrudes into the cavity about a millimeter, 

 while the other two are slightly larger and he between 

 the amnion and the chorion. 



(5) The chorion, amnion and villi are present, the latter 

 being stuck together by an irregular mass of fibrin, blood, 

 and trophoblast, which is scanty. The embryonic mass 

 is irregular and dissociated, and the crelom is not sym- 

 metrical. The spinal cord and brain are dissociated and 

 are not sharply defined, and the heart is probably atrophic. 

 The yolk-sac is degenerate. 



No. 723a. 



(1) L. L. Iseman, Chicago, Illinois. 



(2) A 22X19X17 mm. 



(4) The small chorion measures 22X19X17 mm., and 

 is covered with long, irregular villi. The specimen, 

 which had been opened, contained a transparent body 

 composed of several membranous sacs, which together 

 measure 4 mm. in diameter. Within these sacs were a 

 few granules, one more opaque than the rest. 



(5) The chorion is covered with but few villi, although 

 there is a great tuft of them opposite the attachment of 

 the embryonic mass. Most of the villi have undergone 

 mucoid degeneration. The trophoblast is plentiful, and 

 between the villi there is considerable mucoid matter 

 and blood. The embryonic mass consists of a collapsed 

 amnion and a degenerated cord, to which is attached a 

 nodular embryo containing spaces, the ccelom, an epi- 

 thelial tube and possibly the alimentary canal. 



(6) Hydatiform degeneration. Decidua absent. 



Nos. 788 a, b. 



(1) Anfin Egdahl, Menominie, Wisconsin. 



(a) Ovum 60X45X40 mm.; stunted em- 

 bryo 17 mm. CR. (See Group 6.) 



(2) Twins 



(b) Ovum 65X55X40 mm.; nodular em- 



bryo 2 mm. long. 



(3) Norwegian woman aged 32 years, married 10 years. 

 Three previous pregnancies. This abortion, which is the 

 first, occurred July 2, 1913. Condition of uterus normal. 

 No history of venereal disease. First twins known in 

 family. 



(4) b. This specimen measures 65X55X40 mm., 

 and is composed of chorion covered with degenerate 

 villi. The wall is thin and lined throughout with the 

 amnion. The cavity is filled with transparent fluid, 

 within which was found floating a small vesicle 3 mm. in 

 diameter. On one side of this vesicle is a small nodule. 

 Otherwise no trace of an embryo was found. 



(5) The chorion is thickened, and the mesenchyme of 

 most of its villi is fibrous. The trophoblast is scattered in 

 large nodules between the yilli. The centers of these 

 nodules have undergone fibrinoid degeneration and con- 

 tain large plaques of nuclear dust. The decidua is some- 



