CYLINDRICAL CYEMATA. 



139 



At no place is the amnion attached to the chorion, nor are 

 there indications that they have been torn apart. 



(6) Early hydatiform degeneration and maceration. 

 Decidua absent. 



No. 252. 



(1) D. S. Lamb, Washington, District of Columbia. 



(2) B 3 mm. 



(3) "First pregnancy in an unmarried woman 23 years 

 old. Patient missed one month, then had free hemor- 

 rhage which continued for a month, when the embryo was 

 expelled." This would make its age three months, count- 

 ing from the last period. 



(4) This remarkable specimen shows to what extent an 

 embryo may grow after its regular development has been 

 arrested. It came to the laboratory attached to a solid 

 body and appears to be about 3 weeks old. The free end 

 of the embryo is bent upon itself, and tapers to a point 

 where two intensely black spots may be seen. 



(5) The membrane or body behind the embryo is un- 

 doubtedly the thickened, curled-up amnion; for on the 

 side towards the embryo it is covered with epithelium, 

 which continues over the body. On the other side the 

 mesoderm, which is thickened and hyaline, is free, there 

 being no border cells or villi. The skin is markedly thick- 

 ened, the epidermis in some places forming small papilla? 

 and in others depressions where pearl-like bodies similar 

 to those of epithelial cancer are found. Within the 

 body there is a large cavity filled with round cells. Near 

 its attachment to the amnion several such "abscess-like" 

 masses lie within the embryo. The pigment dots, on 

 account of their position, undoubtedly represent the eyes. 

 Each forms a small sac immediately below the skin, filled 

 with large, free pigment cells. Deeper within the head 

 a band of pigment cells, which may be the optic nerves, 

 connects the eyes. 



No. 288a. 



(1) H. Brulle, Baltimore, Maryland. 



(2) A 85X35X35 mm.; B 11 mm. CR. 



(4) On one end of the chorion there is a space (30X30 

 X 5 mm.) filled with reticular magma. Within this, and 

 pushed to one side, may be seen a collapsed ovum. The 

 intervening space is filled with blood, through which 

 ramify a few long, slender villi. These are fibrous and 

 devoid of blood vessels. At points they are invaded by 

 syneytium and leucocytes. The amnion, which is also 

 fibrous, is partly filled with magma re'ticule' and is very 

 rich in degenerated migrating cells from the embryo. 

 The disintegrating embryo is pushed to one side of the 

 chorion and is pretty well dissociated, but the tissues are 

 sharply enough defined to show that it is not over 6 weeks 

 old. They are well infiltrated with round cells which extend 

 into the surrounding magma. The epidermis is absent. 



(6) Infiltration. 



No. 289. 



(1) H. Brulle, Baltimore, Maryland. 



(2) B 8 mm. 



(4) The specimen is distorted, very dissociated, and 

 macerated. Limb-buds are merely indicated, and the 

 outlines of the organs are almost entirely obscured. 



(6) Decidua and chorion absent. 



No. 297. 



(1) D. S. Lamb, Washington, District of Columbia. 



(2) B 6 mm. 



(3) This specimen was removed from the uterus with a 

 curette and is said to be nearly 3 months old. 



(4) The distorted embryo is of the 3-weeks stage and 

 shows extreme changes in its organs and tissues. 



(5) The chorion is thin and atrophic. There is no trace 

 of an umbilical cord, but instead the embryo sits upon the 

 amnion. The spinal cord is dilated and the brain is fully 

 dissociated, filling up the stumpy head entirely. The 

 blood-vessels are much dilated with blood, and all of the 



tissues are infiltrated with round cells which deform the 

 organs and obscure their outlines. The mandible is ne- 

 crotic, and the distended medulla reaches almost to the 

 mouth. 



No. 302. 



(1) M. Brodel, Baltimore, Maryland. 



(2) A 25X20X15 mm.: B 4mm. 



(4) The ovum is normal, apparently, but is covered with 

 irregular villi. Sections show, however, that these are 

 nbrous and contain remnants of blood-vessels. The tro- 

 phoblast is very active and the villi are partly surrounded 

 by a recticular mass of mucus, rich in leucocytes. 



(5) The amniotic vesicle, which is 10 mm. in diameter is 

 embedded in much magma reticule' and filled with granular 

 magma, in which is an embryo about 3J/2 weeks old. The 

 umbilical vesicle is degenerated and lies in the reticular 

 magma. The blood-vessels and tissues of the embryo are 

 gorged with blood and the outlines of the organs are oblit- 

 erated. The brain is partly solid and the spinal cord dis- 

 tended and dissociated. The eye vesicle and lens are nearly 

 destroyed. The umbilical cord is very short and wide 

 without marked blood-vessels, but infiltrated with round 

 cells. 



No. 312. 



(1) E. M. Stanton, Albany, New York. 



(2) A 25X15X10 mm.; B 8mm. (straightened). 



(3) Abortion followed a blow upon the abdomen. 



(4) One side of the ovum is very hemorrhagic, the other 

 side thin. 



(5) The villi are few in number, without a syncytial 

 covering and possibly invaded by leucocytes. The main 

 wall of the chorion appears to be necrotic. The embryo 

 is straight and shows three gill arches and some myotomes. 

 Its tissues do not stain well, but the spinal cord can still 

 be outlined. The tissues appear to be infiltrated with 

 round cells. 



No. 321. 



(1) A. C. Wentz, Hanover, Pennsylvania. 



(2) A 40X40X20 mm.; B 2mm. 



(4) The ovum is covered entirely with villi and contains 

 some reticular and much granular magma. 



(5) The whole chorion is lined by the amnion and the 

 embryo is attached to it at its middle. Traces of the cen- 

 tral nervous system can still be seen, and in front of it 

 there is a structure which may represent the heart encir- 

 cled by a large space the coelom which extends to the 

 umbilical cord. The tail end of the embryo is nearly solid. 

 A large share of the dissociation may be due to the dilute 

 alcohol (50 per cent) in which the embryo had been placed 

 10 days before it was received at the laboratory. This, 

 however, could not alter the general shape of the embryo 

 and its attachment to the chorion. 



(6) A very macerated hydatiform degeneration. Decidua 

 is absent. 



No. 328. 



(1) A. G. Pohlman, Bloomington, Indiana. 



(2) B 4.5 mm. 



(5) The chorion is covered with irregular, fibrous villi, 

 surrounded by a necrotic decidua more or less infiltrated 

 with leucocytes. The main wall of the chorion is about 

 normal in structure and contains numerous blood-vessels. 

 Within, the amnion nearly reaches the chorion. The de- 

 generated umbilical cord is attached to the amnion, but 

 not to the chorion. The umbilical vesicle is well embedded 

 in magma, is very rich in blood-vessels, and on its outside 

 has many papilliform processes, some of which seem to 

 blend with the chorion. In fact, it appears as if the blood- 

 vessels of the umbilical vesicle passed directly over into 

 those of the chorion. The embryo is somewhat deformed, 

 and it is difficult to follow the outlines of some of its 

 viscera. The central nervous system is dilated and con- 

 verted into a mass of round cells lying in the mesoderm, 

 without any epithelial lining; the otic and optic vesicles 



