140 



STUDIES ON PATHOLOGIC OVA. 



are likewise filled with round cells. The larger vessels are 

 filled with blood, and the tissues are fairly well infiltrated 

 with round cells. The epidermis is intact. Dissociation 

 of the tissues has taken place to such a degree that it is 

 difficult to outline the organs with certainty. 

 (6) Infiltration. 



No. 340. 



(1) C. S. Minot, Boston, Massachusetts. 



(2) B 6 mm. 



(5) The embryo is infiltrated with round cells, and the 

 dissociation of the tissues is quite complete. Large blood- 

 vessels can still be outlined, but the central nervous system 

 is practically solid. 



No. 347. 



(1) C. S. Minot, Boston, Massachusetts. 



(2) A 40X35X30 mm.; B 11 mm. 



(5) The decidua is hemorrhagic and necrotic at points 

 and well infiltrated with leucocytes. The scattered villi 

 and main walls of the 'chorion are fibrous, and at some 

 points infiltrated with leucocytes. Very little syncytium 

 is present, and but few traces of blood-vessels are found 

 in the chorion. The villi are non- vascular and partly 

 matted. The embryo is dissociated and macerated, with 

 dilatation of the central nervous system and extension of 

 the medulla. The blood-vessels are distended and the 

 blood-cells are continued through their walls into the 

 surrounding tissues. 



(6) Slight infiltration of the decidua. 



No. 366. 



(1) A. G. Pohlman, Bloomington, Indiana. 



(2) B 9 mm. 



(5) Sections of the chorion, which is fleshy in appear- 

 ance, show that its main wall is very thin and lined with 

 amnion. The villi, few in number, are fibrous or hyaline 

 and covered with some syncytium, while the spaces be- 

 tween them are filled with blood. Some of the villi adhere 

 by means of the trophoblast to the decidua, which is 

 fibrous and necrotic. There is no leucocytic infiltration 

 of the chorion nor of the decidua. The embryo is pretty 

 well infiltrated with round cells and the tissues are dis- 

 sociated. The latter are, however, well preserved and 

 appear to have been very much alive. There is a consider- 

 able quantity of blood within the cavity of the heart and 

 in the blood-vessels. The central nervous system is dis- 

 sociated. The lower jaw is large and adherent to the head 

 above, and to the trunk below. The arms and legs are 

 atrophic. 



(6) Hydatiform degeneration; specimen very degene- 

 rate. 



No. 398. 



(1) C. R. Bardeen, Madison, Wisconsin. 



(2) B 5 mm. 



(5) The embryo is of the 3-weeks stage, but markedly 

 changed. Most of its organs can still be recognized and 

 the embryonic ccdom is fairly definite. The front of the 

 head is adherent to the thorax below, and the face is pretty 

 well atrophied. The central nervous system is dissociated 

 and distended, as are also the heart, the blood-vessels, and 

 the liver. 



No. 399. 



(1) A. S. Thompson, Mount Horeb, Wisconsin. (Bar- 

 deen collection.) 



(2) B 4 mm. 



(3) Patient 20 jears old, married 10 months. She is a 

 marked bleeder; otherwise strong and healthy. The pelvic 

 organs are normal. The last period occurred during the 

 first week in September and the abortion followed Oc- 

 tober 9. 



(4) The external form looks much like that of a chick 

 embryo. 



(5) Sections show that the tissues are generally disso- 

 ciated and also macerated. 



(6) No decidua or chorion. 



No. 400. 



(1) G. J. Kaumheimer, Milwaukee, Wisconsin. (Bar- 

 deen collection.) 



(2) B 3.5 mm. 



(3) Last menstruation October 21; abortion De- 

 cember 19. 



(4) The external form is that of a normal embryo, but 

 the sections show that marked changes have taken place. 



(5) The central nervous system is distended and partly 

 filled with round cells. The walls of the brain are disso- 

 ciated and apparently are giving rise to the numerous 

 round and fragmented cells which are present. The heart 

 and large blood-vessels are distended and well filled with 

 blood. The tissues of the mesoderm are generally filled 

 with round cells, as well as with numerous fragmented 

 nuclei, the infiltration including the myotomes and peri- 

 toneal cavity. The amnion and epidermis are intact. 



(6) Decidua and chorion absent. 



No. 413. 



(1) A. R. Stevens, Baltimore, Maryland. 



(2) B 5 mm. 



(4) The ovum measures 35X25 mm. and is covered 

 with numerous long atrophic villi. It contains a large 

 amnion, measuring 17 mm. in diameter, which encircles 

 a stunted and twisted embryo 5 mm. in length. The 

 embryo is curled upon itself at the lower end, being sessile 

 upon the amnion, but the head and neck are straight and 

 in many respects appear to be normal. 



(5) The arm-buds appear very much like those of a nor- 

 mal embryo of this size, but the brain is completely dis- 

 sociated, forming an even layer of cells throughout the 

 neural canal. In fact, the only structure in the embryo 

 that is pronounced is a very sharp pericardial cavity 

 containing an atrophic heart. It is impossible to outline 

 any other organs within the body save the spinal cord. 

 There is a fairly sharp outline of its cells in the tail of the 

 embryo, where it spreads out into a wide open plate form- 

 ing spina bifida. This is a case of stunted embryo with 

 spina bifida and almost complete dissociation of tissues. 



(6) Decidua absent. Hydatiform degeneration. 



No. 414. 



(1) J. R. Laughlin, Hagerstown, Maryland. 



(2) A SOX 20X20 mm.; B 6mm. 



(3) Patient is 32 years old and the mother of four living 

 children. She had one miscarriage at 4 months three 

 years ago. There is no specific history. The last men- 

 struation occurred August 28 and the abortion November 8 . 



(4) The ovum is transparent and entirely covered with 

 scattered, ragged villi. It contains a deformed embryo 

 6 mm. in length. The head is normal in shape, but the 

 body is atrophic. The arm-buds are large, but the leg- 

 buds are too small for an embryo of this size. The ccelom 

 is filled with reticular magma. 



(5) Sections of the embryo show extensive dissociation 

 of the tissue. The nervous system is practically solid, the 

 brain being greatly reduced in size. The eye-vesicles also 

 are atrophic, reaching from the brain to the skin as delicate, 

 trumpet-shaped bodies. The optic cups contain vascular 

 lenses. Within the tissue of the embryo many of the 

 blood-vessels can still be outlined by the presence of blood 

 corpuscles within them. The heart is solid and more or 

 less atrophic, and the ccelom fairly well outlined. The 

 body is directly continuous with the amnion, there being 

 no umbilical cord. The coclom of the embrjo communi- 

 cates very freely with the exoccelom, and at the point of 

 communication the intestines extend into the latter. 

 Adjacent to the intestines there is a very small atrophic 

 umbilical vesicle. There is no lumen, the Wolffian bodies 

 can barely be made out, and the liver is completely dis- 

 sociated. The amnion is greatly thickened at points, but 

 the chorionic wall appears normal in structure and thick- 

 ness. The villi are somewhat fibrous, the trophoblast 

 scanty, and there is a small amount of mucoid substance 



