168 



STUDIES ON PATHOLOGIC OVA. 



Had no menstrual period after the birth of last child, 

 November 10, except one day in January, and once, 

 April 14, after a fall downstairs. After this a slight flow 

 every two weeks. Nausea February 28 and March 22; 

 abortion June 3. Accidental abortion from fall and there- 

 fore no infection. No venereal diseases. 



(4) The chorion, which measures 80X70X50 mm., 

 is entirely covered with well-formed villi, and appears to 

 be normal. The contained fetus, measuring 75 mm., is 

 badly macerated. It has a much-twisted and very slender 

 umbilical cord, and there are large blebs on the right leg 

 which appear to be abraded over the knee. 



No. 960. 



(1) G. C. McCormick, Sparrows Point, Maryland. 



(2) B 190 mm. 



(3) Negro woman, aged 31 years; married April 6, 

 1914. Has been pregnant six times; no abortions. Last 

 period February 18 to 22, 1914; abortion October 17 

 following. 



(4) An encephalic fetus apparently at term. Crown of 

 head devoid of scalp, exposing an area 40X60 mm. of 

 blighted brain and its membranes. Over the sacral 

 region there is an area devoid of integument. 



No. 964. 



(1) Henry F. Cassidy, Roland Park, Maryland. 



(2) B 115 mm. 



(3) Negro patient, aged 24 years; married March 20, 

 1911. Two pregnancies, both ending in abortion; the 

 first in 1913 at 3 months. Last menstrual period March 

 22 to 25; abortion October 19, 1914. Bled September 3, 

 and intermittently after October 6, apparently a natural 

 flow in time and amount. No history of venereal disease. 

 Family fertile. 



(4) The specimen consists of a macerated, flattened, 

 and distorted embryo with umbilical cord 280 mm. long, 

 and detached placenta 80X65X35 mm. On section the 

 uterine surface of the placenta presents a firm white 

 marginal layer of decidua, 2 mm. thick, thrown in rugse. 



(5) The villi of the placenta are normal in shape, but 

 closely packed together with trophoblast, and nearly all 

 of them have undergone fibrinoid changes. The mesen- 

 chyme is fibrous and there are many plaques of nuclear 

 dust. There is some blood in the intervillous spaces. This 

 stains black with the Heidenhain method. The tropho- 

 blast in contact with it shows no activity whatever. 



(6) Slight infiltration of the decidua; probably luetic. 



No. 971. 



(1) G. C. McCormick, Sparrows Point, Maryland. 



(2) B 92 mm. 



(3) Patient aged 26 years; married December 31, 1903. 

 Three pregnancies two births at full term and this 

 abortion. Last menstrual period May 24 to 27, 1914, 

 abortion October 29 following. Condition of uterus good. 

 No venereal diseases. Family fertile. 



(4) The specimen consists of a placenta, amnion, and 

 a compressed, greatly macerated, attached fetus. The 

 placenta is very firm. The cord is about 130 mm. long and 

 not greatly twisted. The extremities are flattened and 

 contorted, the legs being badly bent upon themselves. 

 Most of the epidermis has fallen off, and the fetus in 

 general is shrunken. 



(5) Sections through the placenta at the attachment of 

 the cord show the villi to be very fibrous, degenerate, and 

 matted together by a uniform mass of fibrinoid substance, 

 in which there are numerous plaques of nuclear dust. 



No. 979. 



(1) James A. Melvin, Baltimore, Maryland. 



(2) B 210 mm. 



(4) The specimen consists of a badly macerated fetus 

 attached to a placenta which measures 130X100 mm. 

 The fetus is discolored and distorted and the cord greatly 

 twisted. 



(5) The chorion is very fibrous and most of the tropho- 

 blast necrotic. The villi are matted together with exten- 

 sive masses of fibrinoid substance, withm which are large 

 plaques of nuclear dust. The decidua is thin and some- 

 what inflamed, and the placenta itself is practically dead, 

 there being no buds of syncytium at the point where the 

 trophoblast comes in contact with the fresh blood. 



(6) Slight general infiltration of the decidua; some sug- 

 gestion of lues. 



No. 983c. 



(1) J. F. Hempel, Baltimore, Maryland. 



(2) B 103 mm. 



(4) The specimen consists of a naked fetus with flat- 

 tened and distorted extremities. The eyes are receding 

 and the face has the appearance of a mummy. The cord 

 is irregularly shaped, thin and. fibrous at some points and 

 thick and mucoid at others. Most of the epidermis has 

 fallen off. 



No. 983d. 



(1) J. F. Hempel, Baltimore, Maryland. 



(2) B 97mm. 



(4) Specimen consists of placenta with unopened mem- 

 branes, 100 X 74 X 55 mm. On opening the latter there was 

 found a shrunken and distorted fetus. 



(5) The villi are well formed and appear to be fibrous; 

 between them there is some blood and occasional clumps 

 of nuclear dust. The decidual layer is thin and is attached 

 to the tips of the villi by means of a fibrinoid substance. 

 No active trophoblast is present in any portion of the 

 sections. 



(6) Decidua not infiltrated. 



No. 996. 



(1) H. B. Titlow, Baltimore, Maryland. 



(2) A 72X60X30 mm.; B 100 mm. 



(4) The specimen consists of placenta, membranes, and 

 fetus. The uterine surface of the placenta is pearly white, 

 hard, and corrugated. On cutting this surface it was found 

 to be covered by an external layer about 1 mm. thick, of a 

 firm cartilaginous substance. The cord was twisted 

 excessively, and the extremities flattened and distorted. 



(5) Sections through the chorion at the attachment of 

 the cord show that the villi are fibrous, and that large 

 nodules of trophoblast have undergone fibroid degenera- 

 tion and contain plaques of nuclear dust. Some of the 

 villi are attached to the decidua, which contains several 

 well-defined small abscesses. 



(6) Decidua infiltrated. 



No. 1014. 

 (1) M. Ostrow, Baltimore, Maryland. 



(4) The specimen is an unopened conceptus about 8 

 inches in diameter. The uterine surface of the placenta 

 was gristle-like in consistency and the membranes opaque. 

 The amniotic fluid was brownish and the fetus contorted 

 and macerated. The cord is decidedly tortuous. 



(5) The villi are non-vascular and very fibrous, with 

 an especially degenerate epithelium which shows begin- 

 ning calcification. Some of the larger vessels in the chorion 

 are represented as solid fibrous areas, their lumina being 

 entirely obliterated. Some fairly preserved blood is 

 found between the villi, the stroma of which is represented 

 by a translucent coagulum only. The decidua is too de- 

 generate for further comment. 



No. 1020. 



(1) W. F. Twigg, Cumberland, Maryland. 



(2) CR. 260 mm. 



(3) The last menstruation occurred April 26 to 30 and 

 abortion December 11. The patient declares she felt life 

 September 30. No infection. Abortus is estimated to 

 have been dead 10 days at least. 



(4) Specimen is a macerated fetus with marked abdomi- 

 nal distention, suggesting ascites. It must have been 



