APPENDIX I. 269 



IV. Circulation continued. 

 4. Blood. 



a. Morphology. 



b. Blood gases. 



Note effect of alcohol on tissue respiration. Is dissociation curve of blood 

 changed? 



V. Respiration : 



1. Respiratory center. 



Does alcohol affect the sensitivity of the respiratory center (Lindhard)? 



2. Alveolar air. 



Does alcohol affect the alveolar air? 



a By reason of respiratory center changes or 

 6. By affecting the alkalinity of the blood? 



3. Volume of lungs. 



Does alcohol affect elasticity of bronchial passage or alveoli? 

 a. Tidal air. 

 6. Vital capacity, etc. 

 c. Dead space in breathing. 



4. Respiration-rate, depth, rhythm. 



Spirometer tracings under all conditions (best done in connection with experiments 

 on gaseous exchange). 



5. Rich oxygen mixtures. 



Is respiratory quotient altered by breathing oxygen-rich mixtures, when the 

 (easily and rapidly?) oxidizable alcohol is present? (Pulmonary combus- 

 tion.) 



6. Holding the breath. 



Does alcohol alter "breaking point"- 



a. After breathing high oxygen? 



6. After forced deep breathing? 



Paying special attention to inhaling oxygen containing alcohol vapor. (Leonard 

 Hill.) 



VI. Digestion and secretion : 



1. Motibility of stomach. 



a. X-ray studies. 



b. Effect of alcohol on rapidity of movements and continuance of movements. 



c. Hunger. (Cannon, Carlson.) 



2. Diuresis . 



VII. Nutrition (Metabolism): 



I. Alcohol and general and total metabolism. 

 Effect on character of katabolism. 



a. Respiratory quotient as index. 



If man at rest on high carbohydrate diet on preceding days has respiratory quo- 

 tient niichtern of 0.90, how will alcohol ingestion affect the respiratory 

 quotient? 



Is there a selective combustion for alcohol? If so, respiratory quotient should 

 approach 0.666. 



b. If a ntichtern quotient of 0.78 is obtained by regulation of diet on preceding 



days and alcohol + sugar is given, will quotient 



(1) Rise, indicating prevailing carbohydrate combustion? 



(2) Or fall, indicating prevailing combustion of alcohol? 



c. Relative combustion rates of alcohol and various sugars as determined by above 



method. What amount of various sugars will offset the ingestion of 

 alcohol to prevent lowering the quotient? 

 Effect on amount of katabolism and energy output. 



a. Series of niichtern experiments with respiration apparatus, subject very quiet, 



pulse minimum, etc. 

 Then alcohol and note effect on total katabolism on 



(1) Carbon-dioxide production. 



(2) Oxygen absorption. 



