APPENDIX I. 271 



VII. Nutrition (Metabolism) continued. 



4. Protein metabolism continued. 



d. After-effect of severe muscular work on N output. Is it atVcctcd by ;dcohol 



ingestion? 



Is it exaggerated or not? 

 Compare also N partition under these conditions. 



5. Intermediary metabolism. 



a. Carbonaceous material in urine. 



Any change in character of solids in urine. 

 C : N ratio. Cal : N ratio. 



A possible index of a perturbed intermediary metabolism (Higgins and Bene- 

 dict). 



6. Energy metabolism. 



a. Muscle tonus. Is it altered? Muscle hardness. (Exner.) 



b. As muscular work demands a rapid oxidation of material, increases the ventila- 



tion of the lungs, quickens the circulation, and there is in part at least a 

 selective combustion of carbohydrate, a series of experiments to study 

 the oxidation of alcohol by the body under the influence of intense mus- 

 cular activity is of fundamental importance. 



(1) Is there a selective combustion for alcohol during severe muscular work? 

 With no alcohol the respiratory quotient always tends to rise during 

 severe work. If alcohol is burned in preference to protein, fat, or carbo- 

 hydrates, the quotient would be markedly lowered. 



(2) When alcohol and carbohydrates are ingested and muscular work follows, 

 is the metabolism chiefly of carbohydrate, with high quotient or of alcohol 

 with low quotient? 



(3) In a body depleted of glycogen by severe muscular work 



(a) Is the carbohydrate first stored if fed together with alcohol, i. c., does 

 the respiratory quotient remain low? 



(b) When alcohol is given is there any evidence of formation of glycogen 

 from either protein or fat to replace the store, the maintenance-combus- 

 tion being from alcohol? 



(4) Does muscular work increase the capacity of the body to burn alcohol? 

 To what extent? 



Maximum amount burned? 



During muscular work are larger amounts tolerated before signs (incip- 

 ient) of intoxication appear? 



(5) Is appearance of "second wind" quickened or retarded by alcohol inges- 



tion? 



(6) After-effects of muscular work as influenced by alcohol? 



(a) Rapidity of return to normal metabolism. 



Is rate of return altered, i. e., does alcohol help out on the rapidity of 

 recuperation? 



Is pulse base-line lower or the same after work as without alcohol? 



Do alcohol and glucose superimpose their effects on after-work period 

 or is glucose stored and alcohol burned? Is a larger amount of 

 alcohol burned per hour after work when glycogen supply is low? 



(7) Heart-beat, character of wave, etc., after severe muscular work. Does 



alcohol alter it? 

 Electro-cardiograms, etc. 



(8) Intensity of work. Capacity for w r ork. Endurance. 



Is it affected? Can subject do more or less with alcohol? Maximum 

 working capacity. Bicycle ergometer sprint ! ! How long and how high 

 revolutions per minute? Is the efficiency of the body as a machine 

 based upon the rate of speed with a constant load altered by taking 

 alcohol? Any compensating after-effects? 



In a prolonged fatigue experiment, i. e., riding strong pace and load. How 

 test endurance? Ratio of external muscular work and total energy 

 output? 



