28 ON THE FATE OF THE HUMAN EMBRYO IN TUBAL PREGNANCY. 



There are also two varieties of magma found within the ccelom. On the uterine 

 side of the embryo is a peculiar flaky granular magma which takes on a blue tinge 

 in hematoxylin. The larger flakes are stratified and show alternating lighter and 

 darker zones encircling a central highly stained granule. Occasionally this type 

 of magma is found in other specimens, but the flakes are often very irregular and 

 some of them stain intensely with hematoxylin. On the outer side of the embryo 

 the ccelom is filled with a dense reticular magma. Within this is a large space 

 containing the isolated yolk sac spoken of above. The fibrilke of the magma stain 

 intensely in the Van Gieson stain. 



In sections made in this way it is clearly seen that the magma is composed of a 

 dense network of fibrils. This network reaches through the chorionic membrane 

 to this epithelial covering and bears a distinct relation to the mesoderm cells; in 

 fact it belongs to them. As the mesoderm cells do not always form any marked 

 border around the coelom, but reach into it, they carry with them a denser network 

 of fibrils, showing that the protoplasm immediately around the nuclei is composed 

 of very highly differentiated magma fibrils. In other words, magma fibrils are 

 coming out from the cells of the mesoderm and projecting into the ovum. This 

 observation is fully verified in the pathological ovum of No. 402, in which the indi- 

 vidual magma all arises from the mesoderm of the chorion and radiates into the 

 cavity of coelom. In the pathological magma of this specimen the fibrils are as 

 highly differentiated in the ccelom as are those immediately surrounding the nuclei 

 in the normal specimen, No. 808. 



The necrotic plug between the ovum and the tube wall is very pronounced. 

 It is about 1 mm. thick and 2 mm. wide. Towards the distal end of the tube it 

 thins out and it is probable that this thinness occurs at the point of rupture of the 

 ovum from the tube wall into the tube lumen. The plug itself is stratified, as it is 

 composed largely of fibrils. To the naked eye it appears like a lens. No doubt 

 it represents a similar plug which is formed in the uterus when the ovum implants 

 itself normally. 



NORMAL EMBRYOS 6 TO 9 MM. IN LENGTH. 



To all appearances the ovum of the embryo, 4 mm. long (No. 808), is well 

 attached to the tube wall, but it is impossible to state definitely whether the attach- 

 ment is normal or even whether the ovum is normal, as I do not possess suitable 

 stages which have been studied from this standpoint for comparison. One thing, 

 however, seems to be evident, namely, that there is an excessive amount of blood 

 between the villi of the chorion and that the shape of the chorion is normal. The 

 specimens succeeding this (Nos. 706, 612, 597) contain embryos apparently normal, 

 ranging from 6 to 9 mm. The external form of the embryos appears to be normal, 

 but only one of these (No. 612) was cut into serial sections. In general the 

 embryos of these specimens have been more or less injured, which makes it difficult 

 to pass upon their normality. In all three of these specimens the chorionic wall is 

 very hemorrhagic. In the first specimen (No. 706) the hemorrhagic mass is the 

 size of a walnut. It contains within it an amniotic cavity just large enough to hold 



