THE CIRCULATION OF THE BONE-MARROW. 



45 



(3) The very extensive distribution of large-lumened, thin-walled venous 

 sinusoids, probably forming the real, active, functioning vascular bed of the marrow, 

 is the most characteristic thing about the gross circulation in bone-marrow. The 

 venous drainage is threefold, corresponding to that of the arterial supply. 



(4) A hypoplastic marrow is essential for the analysis of the finer distribution 

 of the blood-channels. In such a marrow can be seen a very extensive inter- 

 sinusoidal capillary plexus, hitherto unsuspected, its normal state being possibly 

 one of collapse. 



(5) The vascular system of the bone-marrow is a closed system, no fenestrated 

 vessel-walls being demonstrable in this series of experiments. 



(6) Endothelium apparently forms a continuous lining throughout the vas- 

 cular ramifications in the marrow, being therefore much more extensively distrib- 

 uted through the medium of the widespread capillary plexus than has been 

 indicated in the usual marrow injections heretofore described. 



(7) The splenic and marrow circulations are contrasted, with a view to showing 

 the fallacy of an analogous comparison of the two. 



(8) The possible significance of the endothelial distribution and occult capillary 

 system of the marrow is discussed. 



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