6 PROCEEDINGS OF THE 



In 3^ minutes re-established, 16 in the minute ; spasms; cry; heart beating. 

 In 4\ minutes, respiration ceased. 

 In 5f minutes, pupils contracting. 

 In 1\ minutes, heart ceased ; dead. 

 Heart twitching as in Exp. I. 



Exp. III. Injected as before 0-015 gr. atrop. sulph., followed in half a 

 minute by 2 minims HCy. 



In g minute, respiration rapid. 



In 1 minute, pupil contracting. 



In 1J minute, opisthotonos very severe. 



In 2 minutes, respiration 32, and labored. 



In 3 minutes, respiration stopped. 



In 5 minutes, dead. 



Es.p. IV. Injected the HCy first, 3 minims. 

 In 1 \ minutes fell over in convulsions. 

 In 2 minutes gave 0-015 gr. atrop. sulph. 

 In 2h minutes, gasping very slowly. 

 In 3 Z minutes, dead. 



Besides these, I also performed four other experiments, in which larger 

 doses were used with the like result, as follows : 



Exp. V. Injected gr. 0-2 atrop. sulph., followed in half a minute by 10 

 minims HCy. Death in 4} minutes. 



Exp. VI. Injected gr. 0-2 atrop. sulph., and in half a minute 5 minims 

 HCy. Death in 4 minutes. 



Exp. VII. Injecled gr. 0-1 atrop. sulph., followed in half a minute by 2 

 minims HCy. Death in 6J minutes. 



Exp. VIII. Injected 0-063 gr. atrop. sulph., followed in half a minute by 

 1 minim HCy. Death in 10 minutes. 



That the rabbits did not die as the result of atropia poisoning, I take for 

 granted, inasmuch as very many experiments on all sides prove them to be 

 unaffected by belladonna in any form, as much as 2 grains of atropia not hav- 

 ing produced death. Their peculiar insusceptibility to atropia therefore 

 eliminates a difficulty often felt in similar experiments, viz., to test which of 

 the poisons killed. It may be objected, then, that as atropia does not act on 

 the rabbit, it cannot be expected to act as an antidote here. Preyer, however, 

 asserts that it does act as an antidote in the case of rabbits, and if proven 

 ' here, it must a fortiori hold good in other animals who are more susceptible 

 to its influence. But in order to test this question, I performed the following 

 experiments on dogs : 



Exp. IX. Injected gr. 1-10 atrop. sulph. under the skin of a small dog, fol- 

 lowed in half a minute by 10 minims HCy. In 2 minutes he fell over with 

 marked opisthotonos, slow and labored respiration, and was dead in 8 min- 

 utes. 



Exp. X. Injected 1-10 gr. atrop. sulph. under the skin of another dog of 

 the same size, followed in half a minute by 7 minims HCy. Fell over with 

 opisthotonos, as in the former experiment, in 3 minutes, and was dead in half 

 an hour. 



Exp. XI. Injected 1-10 gr. atrop. sulph. under the skin of a similar- sized 

 dog, followed in half a minute by 5 minims HCy. Death with the same symp- 

 toms in half an hour. 



Exp. XII. 2 3U P.M. Injected under skin of back of moderate-sized dog 1-20 

 gr. atropite sulphatis. 2.37 2 . No effect appearing, injected 1-10 gr. atrop. sulph. 

 2.40. Pupils dilated. 2.41. Injected minims v acid, hydrocyau. dil. (U.S. P.) 



2.45. Seems uneasy ; licks his chaps constantly from the dryness of the mouth. 



2.46. Can scarcely stand. 2.47. Fell down ; howls; bladder emptied ; breath- 



