townsend: asexual stages of verruga organism 667 



which they supposed to exist. ^^ Jt is further very significant 

 that inoculation of these tissues upon the rabbit's cornea pro- 

 duces no lesion. I'' The lesions produced by these inoculations are 

 toxin-incited, not virus-incited. The original proliferation, in- 

 cited by a toxin resulting from the metabolism of the organism, 

 possesses a specific chemophysical reaction, transmissible within 

 limits to the new proliferation which it induces. 



The sporozoites must also reach the spleen, lymphatic nodes, 

 bone marrow, and liver, as well as the capillaries of the mucous 

 membranes, carried thence by the lymphatic system on their 

 failure to imbed in the subcutaneous tissues. If this happens ex- 

 tensively, internal eruption results. This explains the infarc- 

 tion, necrosis, etc., of the internal organs mentioned, and the 

 articulation and bone pains, so commonly noted in the disease. 

 In most cases the fever and eruptive phases of verruga corre- 

 spond very faithfully in intensity. When this correspondence is 

 not so marked, antibodies have probably aided in greater degree 

 in cutting short the asexual multiplication of the Bartonella in 

 the subcutaneous tissues. 



It appears that we are now, for the first time, getting some 

 tangible evidence as to the etiology of verruga. Those familiar 

 with the facts so far known relating to this unique disease will 

 at once see how perfectly they all fit together, now that we inter- 

 pret the cell-inclusions of the eruption tissues as a part of the 

 schizogonic cycle of Bartonella. Thus the unity of verruga 

 appears to be demonstrated by the known stages of its specific 

 organism. 



12 Ibid., 125-126. 

 i^^Ibid., 130. 



