MEMOIRS OF TOE NATIONAL ACADEMY OF SCIENCES. 7 



Blood and a normal saline solution containing 10 per cent venom, equal parts: The erythro- 

 cytes became circular and the nuclei were discharged. There was only slight ameboid movement, 

 and in forty-eight hours all the corpuscles were destroyed. 



Blood and a normal saline solution containing 1 to 0.2 per cent venom, equal parts, showed 

 the erythrocytes globular aud refractive. In fifteen minutes all the nuclei were discharged. In 

 forty-eight hours the corpuscles were destroyed. 



Blood and a normal saline solution containing 0.2 to 0.01 per cent venom, equal parts, showed 

 the corpuscles apparently normal. In twenty-lour hours all the corpuscles were destroyed. 



THE EFFECT OF VENOM UPON THE BLOOD OF THE CHICKEN. 



Normal blood: The erythrocyte's were oval and nucleated, and in ninety-six hours were 

 completely destroyed. 



Blood and venom, 20 cubic millimeters of each, mixed, showed the erythrocytes darker and 

 the nuclei more distinct and smaller. In twenty-four hours many of the corpuscles were globular, 

 while others were spindle shaped, only a few nuclei being discharged. In two hundred and forty- 

 four hours there was no other change. 



Blood and a normal saline solution, equal parts: There was no apparent immediate change 

 in the corpuscles. In seventy-two hours only a homogeneous mass remained. 



Blood and a normal saline solution containing 10 per cent venom, equal parts: The erythro- 

 cytes were spindle shaped and more refractive and the nuclei were more distinct. In forty-eight 

 hours the corpuscles were all destroyed. 



Blood and a normal saline solution containing 1 per cent venom, equal parts, gave the same 

 result as when the 10 per cent venom was used, except that the complete destruction of the blood 

 occurred in thirty-six hours. 



Blood and a normal saline solution containing 0.2 to 0.01 per cent venom, equal parts, showed 

 no immediate alteration of the corpuscles. ( )nly a few scattered nuclei remained in twenty-four 

 hours. 



THE EFFECT OF VENOM UPON FROG'S BLOOD. 



Normal blood: The erythrocytes were oval, nucleated, and 18 niicrorni dimeters in the long 

 diameter. In forty-eight hours only a few nuclei remained. 



Blood and fresh venom, 20 cubic millimeters of each: The erythrocytes showed a tendency to 

 become spindle shaped and the nuclei to become more distinct. The leucocytes were smaller and 

 the ameboid movement stopped. In seventy-two hours there was slight bulging on the sides of 

 the corpuscles. The shape of the corpuscles was well preserved for two weeks. 



Blood and a normal saline solution, equal parts: There was no immediate effect upon the 

 corpuscles. In twenty-four hours the blood was completely broken down. 



Blood and a normal saline solution containing 10 percent venom, equal parts: Many erythro- 

 cytes became spindle shaped and showed alternate light and dark lines radiating from the nucleus 

 to the periphery of the corpuscles. The leucocytes were normal. In forty-eight hours all the 

 corpuscles were absorbed. 



Blood and a normal saline solution containing 1 per cent venom, equal parts: The erythro- 

 cytes were crenated, although none were spindle shaped. The leucocytes were normal. In twenty- 

 four hours all the corpuscles were broken down. 



Blood and a normal saline solution containing (1.2 to 0.01 per cent venom, equal parts: There 

 was no apparent immediate effect upon the corpuscles. In twenty four hours all the corpuscles 

 were destroyed. 



THE EFFECT OF THE VENOM OF CROTALUS ADAMANTEUS UPON PINE SNAKE BLOOD. 



In the normal blood of the pine snake the erythrocytes are oval and 15 micromillimeters in 

 the long diameter. The leucocytes are small, (J micromillimeters in diameter, with the exception 

 of a few which are about 8 to 10 micromillimeters in diameter. The larger leucocytes had marked 

 ameboid movement. In seventy two hours all the corpuscles were broken down. 



