240 MEMOIRS OF THE NATIONAL ACADEMY OF SCIENCES. 



about 155 pounds. J. F. S. was a chemist, a Canadian by birth. 29 years old, and weighed about 

 150 pounds. The last two had always been total abstainers. The subjects were weighed with- 

 out clothing. 



SYMPTOMS OBSERVED IN EXPERIMENTS WITH ALCOHOL. 



In deciding upon the daily amount of alcohol and its division into doses, the purpose was to 

 give the subjects as much as they could well take without apparent nervous disturbance. As 

 above stated, the quantity of absolute alcohol, about 72 grams per day, was divided into 6 nearly 

 equal doses, of which 3 were taken with the meals and 3 between meals. It supplied about one- 

 fifth of the total energy of the diet in the rest experiments and about one-seventh in the work 

 experiments. On one or two occasions J. F. S. experienced a slight tingling in the ears immedi- 

 ately after drinking the alcohol. On one occasion E. O. complained of a slight feeling of 

 dullness. On one occasion A. W. S. thought he experienced a very slight dizziness. Otherwise 

 neither one was at any time aware of any especial effect of the alcohol upon the sensations in any 

 way. With the exception of the tingling in the ears noticed by J. F. S., it is not certain that 

 any of the symptoms referred to w r ere due to the alcohol. 



As regards the effect of alcohol upon the body temperature and pulse rate in these experi- 

 ments there is little to be said. The only observations made were those by the subjects them- 

 selves, and the difficulty of accurately determining one's own normal pulse rate is well known. 

 The observations of temperature were made with a clinical thermometer in the mouth or axilla 

 by the usual method, which of course does not show the exact average internal temperature of the 

 body. The data obtained with E. O. and A. W. S. were not sufficiently accurate and numerous 

 to be decisive. The observations by J. F. S. were made at frequent intervals and with consider- 

 able care. The results imply a slightly decreased body temperature and increased pulse rate in 

 the experiments with alcohol diet as compared with those with ordinary diet, but the differences 

 are not large. 



The data as observed are recorded in the tables in the appendix. 



GENERAL DESCRIPTIONS OF INDIVIDUAL METABOLISM EXPERIMENTS. 



The data of the experiments with alcohol are given in detail in the appendix beyond. The 

 results are summarized, and brief descriptions of the experiments are given on the following 

 pages. The results of these experiments are here compared with those of similar experiments 

 without alcohol, the details of which are published elsewhere, as indicated in Table 1, which 

 follows. 



LIST OF METABOLISM EXPERIMENTS WITH AND WITHOUT ALCOHOL, AND GROUPING 



FOR COMPARISON. 



Of the metabolism experiments with men in the respiration calorimeter, 13 had for one of 

 their objects the study of the nutritive value of alcohol. The details of 11 of these are given in 

 the present report; those of 2 others have been published elsewhere. These 13 experiments are 

 compared with a like number made with the same men. but without alcohol in the diet. Table 1 

 gives a list of these 26 experiments, with grouping for comparison and references to publications 

 in which the details may be found. 



