252 



MEMOIRS OF THE NATIONAL ACADEMY OF SCIENCES. 



they constitute one long- experiment. No attempt was made to obtain a separation of the feces 

 for the different experiments. The usual separations, however, were made, the first between the 

 preliminary digestion experiment and the beginning of metabolism experiment No. 15, and the 

 second at the close of experiment No. 17. The diet in these experiments consisted of a basal 

 ration which was the same in all 3 experiments, supplemented by alcohol in the form of pure 

 ethyl alcohol in experiment No. 15, by alcohol in the form of whisky in experiment No. 16. and 

 by alcohol in the form of brandy in experiment No. 17. The total diet including the alcohol 

 furnished 109 grams of protein and 2,653 calorics of energy per day. 



The preliminary digestion experiment began January 12. 1899, and continued 1 days as usual. 

 During this preliminary experiment the subject received the basal ration, and in addition to this 

 72.'' grams of absolute ethyl alcohol, which was administered daily in coffee infusion sweetened 

 with 15 grams of sugar. 



The subject entered the respiration chamber on the evening of January 15 and experiment 

 15 began at 7 a. m. January 16. During this experiment he received the basal ration supple- 

 mented by 79.8 grams of 90.9 per cent commercial alcohol, or 72.5 grams of absolute ethyl 

 alcohol, in 775.2 grams of coffee infusion, the whole of which was sweetened with 15 grams of 

 cane sugar. There was 900 grams of the mixture which sufficed for the whole day. This was 

 taken at 6 intervals, the larger portions being consumed with the meals and the smaller portions 

 between meals and just before retiring. 



Experiment No. 16 began at 7 a. m. January 18. and continued 2 days. The diet in this 

 experiment consisted of the basal ration supplemented by 158.3 grams of whisky, with 15.8 per 

 cent, or 72.5 grams, of absolute alcohol. This was mixed with 696.7 grams of water sweetened 

 with 51 grams of sugar, and the whole divided into 6 doses and taken as before. The mixture 

 was made with water rather than with coffee infusion, because it was thought the objection might 

 be raised that the coffee might perhaps, to some extent, counteract the effect of the alcohol. The 

 whisky, sugar, and water were furnished to the subject, who mixed them at the usual hours within 

 the apparatus. The amount of alcohol found in the air current was larger during this experiment 

 than during the one preceding it, suggesting that some alcohol may have been volatilized as the 

 whisky was poured into the drinking cup and mixed with the water. The mixing was therefore 

 clone outside the apparatus in the next experiment, and the alcohol in the air current was again 

 less than in No. 16. 



Experiment No. 17 began at 7 a. m. January 20, and continued 2 days, during which the 

 subject received the basal ration supplemented by 143.8 grams of brandy, with 50.1 per cent, or 

 72.5 grams, of absolute alcohol, per day. This amount was added to 711.2 grams of water and 

 15 grams of sugar, making a total of 900 grams of the mixture, which was administered in 

 6 portions, as in the previous experiments. 



The following table summarizes the results of these 1 experiments. Detailed data of 

 experiments Nos. 15-17 will be found in the Appendix, pages 305 to 317; those of No. 5 will be 

 found in Bulletin 69 of the Office of Experiment Stations: 



Tablk li. — Summary of remits of metabolism < vperiments Nos. 5 and 15-17. 

 [Quantities per day.] 



