394 



MEMOIRS OF THE NATIONAL ACADEMY OF SCIENCES. 



One thing- has impressed us, not only in these experiments but in others, the results of which 

 we have studied. It is that the daily nitrogen balance is a much less reliable indication of the 

 effects of diet, or of drugs, or of muscular work, or of medical treatment than is commonly 

 supposed." 



Table C'XXIII. — ( 'omparison of daily elimination of nitrogen in the urine when alcohol did and did not form a part of 



the diet. 



[Figures in bold face indicate days in which alcohol formed a part of the diet.] 



Experiment and 

 subject. 



I'.. ( ). 



Experiment Nos. 



13 and 14 



Experiment No. 



Experiment N< >. 



9 



Experiment No. 



10.. 



Experiment No. 



11 



Experiment No. 



12 



Experiment No. 



Experiment Nos. 



1.5-17 



Average 13 and 



14, 9, 11, 5.... 

 Average 7, 10, 



12, 15-17 



Experiment Nos. 



22-24 



A. W. S. 



Experiment Nos. 



4a-4c 



Experiment Nos. 



18-21 



J. F. S. . 



Experiment Nos. 



26-28 



Experiment Nos. 



29-31 



Experiment Nos. 



32-34 



Average 26-34... 



Gms, 



16.9 



16.7 



19.1 



19.8 



19.9 



19.3 



19.1 



17.4 



18.8 



18.3 



19. 



15. 3 

 15.5 



15.9 



16.0 



16. 1 

 16.0 



Nitrogen in urine, pre- 

 liminary period. 



Gm. 

 15.3 



17.4 

 17.6 

 12.5 

 10.1 

 17.2' 

 11.6 

 15.6 

 13.1 

 17.3 



15.0 

 12.2 



16. 6 



13.9 



15.0 

 15.2 



67m, 



16. 



19.1 



22.1 



20.5 



11.7 



15.4 



17.6 



16.0 



16.9 



17.8 



18. 



15.6 

 16.0 



15.9 



15. 5 



15.5 

 15.6 



67ms. 



17.2 



15.9 



20. 1 



12.3 



13.6 



13.8 



14.2 



13.9 



it;.:; 



14.0 

 14.6 



14.3 

 19.0 



15. 

 15.0 



15.6 



15.4 



67ms, 



20.2 



18.5 



17.9 



14.2 



13.8 



18.3 



23.8 



10.4 



18.9 



15.4 



13.7 



14.4 

 16.4 



16.0 



14.8 



15. 1 

 15. 3 



Nitrogen in urine, calorimeter period. 



Nitrogen in urine, 

 average. 



20.2 

 19.6 



is 



19.7 



17.5 



17.9 



20. 3 



15.1 



19.2 



18.1 



18.7 



14.6 

 17.4 



m. ii 



15.4 



16.3 



16.1 



Gms 



17.4 



17.8 



18.8 



20.6 



17.1 



21.3 



17.4 



16.2 



17.7 



19.0 



18.8 



14.1 

 15.4 



15. 1 



16. 3 



15.3 



15.6 



'.in: 1. 111. 



16.9i 16.5 



16.2 17.3 



18.3 17.9 



13.1 



14.7 



14.4 



16.2 



15. ii 

 15.4 



15.7 15.6 



13.7 

 14.2 



14.6 

 16.8 



19.6 



12.6 



13.8 



15.5 

 18.0 



16.7 17.6 

 16.0, 17.0 



Gms. 



18.5 



11.9 

 14.4 



19.4 



12.4 

 14.5 



16.8 15. 9 



17.1 16.3 



17.717.4 

 17.216.5 



18. 1 



13.1 

 16.2 



Gms. 



17.3 



11. 

 15.4 



15. 2 14. 7 



15.4 



15.2 



16.3 16.4 



15.615.4 



Gms. 

 17.2 

 17.8 

 19. 4 

 16.2 

 12.9 

 14.4 

 18.2 

 13.0 

 16.9 

 15.4 

 16.1 



Calorimeter 

 period. 



Gms. 



17. s 

 17.7 

 IS. 4 

 19.5 

 is. 1 

 18.2 

 IS. 1 

 15.6 

 18.1 

 17.7 

 18.5 





si 



19.5 



18.1 



18.2 



is. 1 



15.6 

 18.1 



14.8 13.0! 



15.9 15.0 



16.0 

 14.8 



15.3 



15.4 



15.4 



16.3 



16.6 

 16.1 



is. 1; 



13.0 

 15.4 



15.3 

 15.8 



16. 2 



15.S 



17.8 

 18.4 



15.0 



15.6 



17.3 



17.3 

 16.7 



1 My own confidence in the results of the experiments of a few days' duration as indications of the influence of 

 any such agencies upon nitrogen metabolism was much shaken by the experience of Dr. C. F. Langwokthy and 

 myself in collating and comparing the results of experiments on these subjects in the course of the preparation by 

 ourselves of Bulletin 45 of the Office of Experiment Stations of the United States Department of Agriculture, A 

 I'iur-i of Metabolism Experiments in which the Balance of Income and Outgo was observed. The tables of this 

 volume include summaries of 2,299 experiments with men ami 1.3(12 with animals, in which the nitrogen balance 

 was studied. The very clear impression left upon my own mind is that a not inconsiderable share of the conclusions 

 reached by the authors of this very large amount of painstaking inquiry must be held subject to revision in the 

 light of inquiries in which the experimental periods will be longer and the determinations more detailed. — W. O. A. 



