54 



MEMOIRS NATIONAL ACADEMY OF SCIENCES, VOL. X, NO. 3. 



Experiment 18. — Very young dog, weight 6.006 kilograms. 



In looking over the foregoing experimental record, it will be seen that in Experiment ltf, 

 under the influence of 8 c. c. of 25 per cent alcohol, there was a decrease in the time required to 

 till the stromuhr of from twenty-one to fourteen seconds, or, in other words, an increase of 33 per 

 cent in the rapidity of the. flow of the blood. This increase in the rapidity of the flow of blood 

 was maintained after the further injection of 5 c. c. of alcohol, but gradually lessened on the 

 repetition of the dosage, so that after 36 c. c. of the alcohol it had practically disappeared. The 

 paralyzant influence of the alcohol then became more and more apparent, and when 15 c. c. in 

 addition to that previously used had later been injected, the rate of flow through the artery was 

 less than half of the norm. 



In Experiment 17, in a dog weighing S kilos, 9 c. c. of alcohol reduced the time necessary 

 for the tilling of the stromuhr from twenty-two to fourteen seconds- -i. e., increased the rapidity 

 of the blood flow a little over 33 per cent. It is remarkable that the further injection of 35 c. c. 

 of alcohol had no further effect upon the rate of the blood current, but when 12 additional c. c. 

 were subsequently given the flow came down to about the norm. 



Experiment l!-i was a more complicated one than the others. In it the blood pressure was 

 studied at the same time as the rate of blood flow. The administration of 1 c. c. of alcohol 

 brought down the time necessary for the filling of the stromuhr from thirty-five to fifteen 

 seconds: in other words, more than doubled the rate of flow. When 6 c. c. of additional alcohol 

 had been given, the increase of the rate of flow decreased until finally the paralyzant effect of the 

 alcohol upon the circulation became very apparent, so that seventy-four seconds were required 

 to till the stromuhr instead of thirty-five, the norm. It should be noted that the changes in 

 the rate of flow were not paralleled by any changes in the arterial pressure. A peculiarity of 

 this experiment is the extraordinary effect reached by the injection of a very small amount of 

 alcohol. It should be noted, however, that the dog which was experimented upon was not only a 

 very small dog, weight 12 pounds, but that it was also a very young puppy, and therefore 

 presumably abnormally sensitive to the influence of drugs. 



SERIES SIXTH. 



In studying the action of alcohol upon the isolated frog's heart we have used successively 

 the various forms of apparatus known to us, in order to reach results which should be as far as 

 possible free from fallacies, and to discover the possible sources of the difference of the reports 

 made by other observers. 



We have made a number of experiments with the ordinary Kroneker apparatus. Unfortu- 

 nately, in the moving from the old to the new University of Pennsylvania laboratories, all the rec- 



