72 SCIENCE PROGRESS 



adrenalin, was formed by reducing XIV with sodium and boil- 

 ing alcohol, but could not be crystallised. Its physiological 

 activity was found to be only about twice that of the keto form, 

 reduction in this case not being accompanied with that enormous 

 increase in pressor action which occurs in the case of adrenalin. 



a>-Amino-0-hydroxyacetophenone and &)-amino-0/>-dihydroxy- 

 acetophenone were also produced. The former was found to 

 have very slight haemostatic action, and the latter an effect 

 equal to that of the corresponding /(-hydroxy compound. From 

 which it appears that the hydroxyl group in the ortho position 

 exerts no influence on the physiological activity of the substance. 



Although it is often felt that the advance of organic chemistry 

 is no longer rapid, such investigations as these indicate the field 

 in which brilliant achievements may still be expected. 



