THEORIES OE IMMUNITY. 



lymphatic glands and also in the hyaline cells 

 lying free in the lymph sinuses, which later may 

 be connected with some at least of the large 

 mononucleate hyaline cells of the blood. He 

 further points out that similar hyaline cells — en- 

 dothelial cells, connective cells — proliferate dur- 

 ing infection, as can be shown by mitotic figures 

 beinix found. It is no doubt the case that in 

 different infections different groups of cells thus 

 proliferate : in typhoid fever, for instance, there 

 is no polymorphonuclear reaction, but here the 

 proliferation of endothelial cells and hyaline 

 cells in lymphatic glands -has been observed. 

 Thus while Metchnikoff has insisted with justice 

 on the importance of the local reaction and of 

 the wandering cells of the body in infections, 

 and has noted the occurrence of phagocytosis 

 in other cells (his fixed ameboid cells), he has 

 missed the fact of the great proliferative changes 

 in various parts of the body which may be de- 

 scribed as the reaction of the body generally 

 against infection. It must be insisted upon that 

 there are not only local chemiotactic effects, but 

 in the case of the wandering cells there is the 

 sreneral chemiotactic effect which draws the 



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