442 SCIENCE PROGRESS. 



peculiar proteine, but that other bodies associated with 

 this may assist to produce a reaction which is considered 

 as diagnostic. 



These experimental results were obtained by working 

 with one species of animal, and, according to Schindelka 

 (20), they are not true for horses. On injecting proteines 

 identical with those employed by Schattenfroh into three 

 horses free from glanders, a considerable febrile attack was 

 produced, and on a glandered horse the effect was negative. 

 Mallein acted in an inverse manner, and this observer con- 

 siders that inquiries into the relative value of mallein and 

 other bacterial products only strengthen the evidence in 

 favour of mallein. 



The interest which attaches to bacteriological research 

 lies in part, if not wholly, in the solution of the problem 

 of immunity, and in the experimental work which directly 

 aids in the treatment of disease. In glanders neither of 

 these aims has as yet been accomplished. The results 

 obtained by Babes, who claims to have rendered guinea- 

 pigs immune to glanders by treatment with minute in- 

 jections of mallein, have not been confirmed. According 

 to the same observer guinea-pigs can also be cured of 

 glanders by administration of this substance ; and two 

 horses suffering" with the chronic form of the disease were 

 also cured. The majority of observers are, however, agreed 

 that no therapeutic effect follows treatment with mallein. 

 Favourable results may follow, but since spontaneous 

 recovery from this disease may take place a possible fallacy 

 is not excluded. Schattenfroh and others have shown that 

 mallein has no therapeutic power, and in this as well as 

 in many other characteristics this substance resembles 

 tuberculin. 



As a diagnostic measure mallein appears to have an as- 

 sured position. A recent paper, published by Foth (21) 

 last August, reviews this question at length. Nearly all 

 observers point out that animals suffering with acute or 

 chronic glanders, or even with the mild condition spoken of 

 as latent, may exhibit a reaction to small doses of mallein. 

 The symptoms produced in glandered horses, according to 



