502 SCIENCE PROGRESS. 



We see, then, that these two closely related classes of 

 compounds, iodides and bromides, are fundamentally dif- 

 ferent in their behaviour with relation to the dog's organ- 

 ism. The bromides are taken up by the cells, where they 

 can replace the chlorides, and in the cells of the gastric 

 glands they are split up into free acid and alkali, just as are 

 the chlorides. Since they are thus built up into the living 

 framework of the body, their elimination is slow. The fact, 

 however, that dogs die under their administraJon shows 

 that the representation is not complete, and that the animal 

 cell cannot for all its purposes utilise the bromides. 



The iodides, on the other hand, cannot replace the 

 chlorides, and are probably only taken up by the cells of 

 the body to a very small degree. They pass through the 

 body in solution in its juices, leaving its cells and their well- 

 being unaffected, and are rapidly excreted in the urine. 

 These few experiments seem to offer us prospects of a 

 further insight into the chemical affinities of living proto- 

 plasm, and it is to be hoped that they are merely the first 

 instalment of a long series of similar comparative experi- 

 ments on the reaction of the living body to allied chemical 



substances. 



BIBLIOGRAPHY. 



(i) PAWLOW, J. P. Beitrage zur Physiologie der Absonderungen. 



Innervation der Bauchspeicheldruse. Du Bois Archiv, 1893, 



Supplement, p. 176. (Russian), 1888. 



(2) Mett, S. G. Weitere Mittheilungen zur Innervation der 



Bauchspeicheldruse. Du Bois' Archiv, p. 58, 1894. 



(3) KUDREWETZKV, B. B. Chemismus der Pankreasabsonderung 



unter dem Einflusse der J^ervenreizung. Du Bois Archiv, 

 p. 83, 1894. 



(4) Pawlow, J. P., and Schoumow-Simanowsky, E. O. Die 



Innervation der Magendriisen beim Hunde. Du Bois' 

 Archiv, p. 53, 1895. 



(5) Schoumow-Simanowsky, E. O. Ueber den Magensaft und 



das Pepsin bei Hunden. Archiv fur Exp. Path., vol. xxxiii., 

 p. 336, 1894. 



(6) Nencki, M., and Schoumow-Simanowsky, E. O. Studien 



uber das Chlor und die Halogene im Thierkorper. Archiv 

 fur Exp. Path., vol. xxxiv., p. 313, 1894. 



E. H. Starling. 



