GLYCOGEN. 319 



contained in the drug- ; and phloretin, a sugar-free derivative 

 of phloridzin, produces diabetes just in the same way. Sec- 

 ondly, it might originate from the hepatic glycogen, but 

 this cannot be the only source, as the drug produces 

 diabetes in fasting animals, and also in those who have 

 been taking it for some days and in which all the glycogen 

 must have been got rid of long ago. Thus the third pos- 

 sible source is alone left, and the sugar undoubtedly comes 

 from proteid. 



But how can proteid give rise to sugar? Is it possible 

 to obtain sugar from proteid in the laboratory ? This is a 

 question which it is not possible to answer fully in the pre- 

 sent article. Suffice it to state that recent research has 

 shown that the answer to this question will probably be 

 found to be an affirmative one. In no case as yet has 

 dextrose been obtained from proteid ; but some recent 

 experiments (12, 13, 14) teach us that sugars other than 

 dextrose are obtainable, and that is a step in advance. 



BIBLIOGRAPHY. 



1. C. Voir and others. Zeitsch. f. Biol., xxviii., p. 245. 



2. F. Voit. Ibid., p. 353. 



3. F. Voit. Ibid., xxix., p. 147. 



4. D. N. PATON. Proc. Roy. Soc, vol. liv., p. 313, 1894. 



5. M. Bial. P finger" s Archiv, lv., p. 434. 



6. SEEGEN. Ibid., xxii., et seq. 



7. NEUMEISTER. Zeitsch. f. Biol., N.F., ix\, p. 347. 

 S. Bial. P fingers Archiv, liii., p. 156. 



9. LEPINE. Conipt. Rend., cxv. (1892, ii.), p. 304; ibid., cxvi. 

 (1893, i.), p. 123. 



10. ARTHUS and HUBER. Archiv de Physiol, 1892 [5] 4, p. 651. 



1 1. Shore and Tebb. Proc. Physiol. Soc, 1892, p. xix. ; Jour, of 



Physiol., xv., p. 42 1 . 



12. KOSSEL. Verhandl d. physiol. Gesellsch., Berlin, 14th Oct., 



1892. 



13. HAMMARSTEN. Zeitsch. physiol. Cliem., xix., p. 19. 



14. Paw. Proc. Roy. Soc, liv. (1893), p. 53. 



YY. D. Halliburton. 



