376 SCIENCE PROGRESS. 



nuclein on gastric digestion. In other words, the substances 

 which have at various times received the names of fibrino- 

 plastic substance, fibrin-ferment, cell-globulin, fibrinogen A., 

 tissue fibrinogen, etc., etc., are all varieties of one sub- 

 stance which is nucleo-albumin, and further, that it is in all 

 cases a nucleo-albumin which, in co-operation with calcium 

 compounds, brings about coagulation in the blood. 



In order to make this review complete, it is now 

 necessary to allude to the recently-published researches of 

 three more observers or sets of observers. 



Wright has devoted himself to what may be an im- 

 portant side issue, namely, the influence of the amount or 

 the tension of carbonic anhydride in the coagulating blood. 

 It is certainly a fact that intravascular coagulation is 

 generally most intense in the veins, where the pressure of 

 this gas is greater than in the arteries. 



Lilienfeld and Kossel, in Berlin, have also turned their 

 attention to nucleo-albumins, and have dubbed them nucleo- 

 histons, on account of a supposed resemblance between 

 histon, the proteid moiety of the material, and peptone. 



And lastly, in conjunction with Dr. Brodie, I have 

 recently published in the. Journal of Physiology 1 an account 

 of some experiments in the same direction, which we have 

 been carrying on at King's College for the last three years; 

 and I propose to conclude this paper by giving a brief 

 summary of our results. 



i. Nucleo-albumins may be prepared from most of the 

 cellular organs of the body (muscle is an important excep- 

 tion) either by Wooldridge's acetic acid method, or by a 

 new method in which alternate treatment of the tissue with 

 sodium chloride and water constitutes the main feature, but 

 for full details of which the original paper must be consulted. 



2. The material obtained by both methods from the 

 same organ is the same in ( i ) general reactions which 

 closely resemble those of a globulin, (2) percentage of phos- 

 phorus, and (3) physiological action, i.e., the production 

 of intravascular coagulation ; death is due to cessation of 



1 Vol. xvii., p. 135. References to other authors will be found in this 

 paper. 



