508 WHERRY AND YANOVSKY: MORPHINE DERWATlVES 



described crystallographically by Arzruni.^ The forms ob- 

 serv^ed were front and side pinacoids, two prisms, front and side 

 domes, and right and rarely left sphenoids, the important angles 

 being, as transformed: ^no = 47^05' and pici = 28° 41', cor- 

 responding to a:h: c = 0.930:1 : 0.509. 



It was found best to recrystallize this alkaloid from ethyl 

 acetate until the melting point became constant at 153° (Gri- 

 maux^"). Fine crystals 2 mm. in diameter were finally obtained, 

 which were measured, with the results shown in table 2. 



TABLE 2. Angle Table for Codeine 

 Rhombic, bisphenoidal; a:h:c = 0.931:1:0.509° 



Description 

 Narrow; often absent 

 Prominent form 

 One prism form 

 Another prism form 

 Small; often absent 

 Dominant terminal form 

 )Well developed, sphen-( 

 ^ ^ ^ "^ ^ oidal, both + and —^ 



" As with morphine the measurements vary =e:2o', so axes are given to but three 

 places. 



The form above described, which we have found to separate 

 also from absolute ether and methyl and ethyl alcohols, is evi- 

 dently the same as that described by Arzruni. 



The marked solubiUty shown by this alkaloid has permitted 

 only rough measurements of the refractive indices as: a = 1.62, 

 iS = 1.63, 7 = 1.65, 7 — a. = 0.03. The axial angle 2E is 

 very large, about 125°; the sign + ; and the dispersion strong, 

 with 2Er> 2Ev These agree with the data of Arzruni. 



CODEINE MONOHYDRATE, C18H21NO3.H2O 



At least six different authors have studied this form of codeine ; 

 and their results have been tabulated and discussed by Hey- 

 drich.^^ The forms which have been observed are the base, a 

 prism with (p = 45° 50' to 46° 15'; two side domes with p = 



5 Zeitschr. Kryst. Min. i: 302. 1877. 



1" Ann. chim. phys. (Ser. 5) 27: 274. 1882.' 



" Zeitschr. Kryst. Min. 48: 270. 1910. 



