WHERRY AND YANOVSKY: MORPHINE) DERIVATIVES 509 



22° 35' to 22° 52' for one, and 39° 12' to 40° 02' for the other; 

 and a front dome with p = 40° 46' to 41° 04'. The prism and 

 the steeper side dome are taken as the unit forms. For the 

 present study crystals were grown from water and from hydrous 

 methyl alcohol, attaining a diameter of 2 mm. The results 

 were: 



TABLE 3. Angle Table for Codeine Monohydrate 

 Rhombic; Probably Bisphenoidal; a:b:c — 0.960:1:0.830" 



" The crystals were somewhat better in this case than in the two preceding ones, 

 and the maximum variation was but =fcio', but previous results have varied so 

 markedly that only three decimal places are used for the average axial ratios given. 



The agreement between these results and the average of 

 those of previous authors is close. 



Codeine monohydrate has been described optically by Kley,^^ 

 by Heydrich^^ and by Wright. ^^ The measurements by the 

 first and last of these authors are admittedly only approximate, 

 because of the solubility, but Heydrich's measurements were 

 made by the prism method, and are more accurate. The im- 

 mersion method gave on our material roughly a = 1.54, /3 = 

 1.64, and 7 = 1.69, 7 — ■ a = 0.15; axial angle 2E very large, 

 around 130°; sign — ; and dispersion distinct, with 2Kr<2Ev. 



CODETHYLINE, MORPHINE ETHYI. ESTER, MONOHYDRATE 



C19H23NO3.H2O 



The ethyl ester of morphine, the hydrochloride of which is 

 known commercially as dionin, has apparently never been meas- 

 ured crystallographically. 



'2 Loc. cit. 

 1' Loc. cit. 

 1^ Loc. cit. 



