WHERRY AND YANOVSKY: MORPHINE DERIVATIVES 



511 



o°oo 

 90°oo 



65°55 

 48°io 

 o°oo 

 o°oo 

 90°oo 

 9o°oo 



9 P 



III 



p 

 90°oo' 

 90°oo' 

 90°oo' 

 90°oo' 

 26°3o' 

 45 ± 

 29°07' 

 48=4= 



Calculated 



suits presented in table 3 and in Fig. i. The orientation 

 adopted is that which brings out the relationship between this 

 substance and the two previously described monohydrates. 



The immersion method yielded the following approximate 

 data for these crystals: Refractive indices a = 1.55, /? = 1.58, 

 7 = 1.65, 7 — a = o.io; axial angle very large, about 125°; 

 sign +; dispersion distinct, with 2Er> 2Ev 



HEROINE, DIACETYIv-MORPHINE, C21H23NO5 = Ci7Hi7NO(CH3COO)2 



The commercial alkaloid was recrystallized until a product 

 with a constant melting point of 171-172° was obtained. (Var- 



TABLE 5- AngIvE Table for Heroine 

 Rhombic, Bisphenoidal; a:b:c = 0.8952:1:0.497" 



Observed 

 Description 



Dominant form 



Narrow, yet well marked 



Narrow prism form 



Dominant prism 



Narrow but definite 



Very small 



Narrow, yet well marked 



Small but defiinite 

 ) Dominant terminal form; \ „o 

 \ both + and — ■ sphenoids ^ 



" The crystals of this alkaloid were more perfect than those of any of the others 

 and the maximum variation on angles was but ±5', the probable error of any one 

 measurement being =±=i'. This permits statement of the axial ratios to the fourth 

 place. 



ious authors give from 169 to 173°.) It was found to crystalhze 

 well from ether, ethyl acetate, and methyl alcohol. No crys- 

 tallographic description of this substance could be found in the 

 literature, so four of the excellent crystals obtained from ethyl 

 acetate were submitted to measurement, with the results pre- 

 sented in table 5, and Fig. 2. 



The crystals obtained from other solvents showed the more 

 prominent of these forms, and the angles agreed within half a 

 degree. 



The optical properties obtained by the immersion method are 

 as follows: Refractive indices: a = 1.56, /S = 1.60, 7 = 1.6 1, 

 7 — a = 0.05 ; the maximum and minimum indices are usually 



o 00 

 90°oo 



65°54 

 48°io 

 o°oo 

 o°oo 

 90°oo 

 90^00 



36°45' 48°io 



p 



90°oo 

 90°oo 

 90°oo 

 90°oo 



26°28 



44°53 

 29°o6 

 48°03 



36°45 



