FOUND GROWING IN LIVING ANIMALS. 281 



or oval globules. Fig. 1, plate VI. represents a portion of such a section, and fig. 7 

 shews how these globules or sporules are given off in various ways. I have seen 

 some oval bodies about twice the size of the others, and some round, both dis- 

 tinctly nucleated. (Fig. 6, a.) The long diameter of the former measured ^ of 

 a millimetre. The sporules agglomerated in masses are always more abundant, 

 and highly developed in the centre of the crust. The cylindrical tubes, on the 

 other hand, are more readily found near the external layer. I have occasionally 

 seen swellings on the sides of the jointed tubes, but whether these are sporules, 

 or the commencement of branches, remains still undetermined. 



Remembering the ill success of M. GEUBY'S inoculations, I thought it right 

 to try whether the disease could be propagated in another part of the individual 

 already affected ; because, if not susceptible of extending in a person already pre- 

 disposed, it was not likely to be caught by one in perfect health. I accordingly 

 made a small puncture in the neck of the boy first spoken of, about an inch below 

 the occipital protuberance, and an inch and a half from the large masses of crusts 

 connected with the scalp. I introduced through this puncture, under the cuticle, 

 some of the broken down yellowish -white friable matter found in the centre of 

 the capsules, which consists principally of the sporules of the plant. The wound 

 healed up in a few days without presenting any thing abnormal. I also inocu- 

 lated my own arm in the same manner, but without any result. I repeated these 

 inoculations twice on the boy and on myself with the matter of the pustules, 

 instead of that of the crusts, but in every case without success. 



It then occurred to me that, as the disease usually appeared in the hairy 

 scalp, it might be more readily produced in that part of the integuments. I 

 therefore had my own scalp inoculated in two places with the pus taken from 

 one of the pustules. It excited inflammation, suppuration, and ulceration. The 

 matter discharged formed hard scabs, which, however, in no way resembled those 

 of the porrigo, or exhibited vegetations when examined with the microscope. 

 After continuing three weeks, during which period one of the sores extended to 

 the size of a shilling, and both ulcerations still spreading, they were destroyed by 

 the frequent application of caustic. I subsequently had my head inoculated with 

 the sporules of the mycodermata, but the wound healed up completely without 

 producing any appreciable result. 



I subsequently rubbed a mass of the white friable matter, constituted of the 

 sporules, upon the arm, so as to separate several of the epidermic scales, and 

 induce erythematous redness. Slight superficial abrasions were produced, which 

 healed in a few days, without presenting any evidence of the mycodermata hav- 

 ing germinated. I also sprinkled the sporules over an extensive accidental abra- 

 sion on the leg, which, however, healed up- in the usual manner. 



Thus, in none of these experiments, performed in various ways, on different 

 portions of the surface, and frequently repeated so as to avoid fallacy, could I 



VOL. XV. PART II. 4 G 



