430 Dr. John Muller' s Examination of [Junk 



not the slightest change in their shape and size. In a 

 saturated solution, however, of carbonate of potash, they 

 appear by degrees to become somewhat smaller. 



When the globules have been treated with acetic acid 

 the nuclei remain, varying in form in the blood of different 

 animals. In the frog these nuclei appear not to be flat, or 

 at least, not perceptibly so. In the salamander they are as 

 distinctly flat as the globules themselves. The nuclei, 

 when their external coat has been removed by acetic acid, 

 have a brown colour, which appears to depend upon some 

 colouring matter still adhering to them, for when treated 

 with water they are white. 



Hydro-chloric acid does not completely dissolve the outer 

 coat of the globules, although it renders them sensibly 

 smaller. Chlorine changes the colour of the blood of the 

 frog, first causing it to assume a brownish hue, and then a 

 whitish colour. Tincture of nutgalls, liquor stibii muriatici, 

 and liquor mercurii muriatici corrosivi cause the globules to 

 shrink. 



A dilute solution of muriate of iron produces no change 

 in the globules. 



Caustic potash does not change their form, but speedily 

 dissolves completely both external coat and nucleus. 



Caustic ammonia dissolves them more rapidly, and when 

 brought in contact with them makes them round. 



Alcohol does not alter the globules. 



Strichnin and Morphia are also inactive. # 



The globules both in the arterial and veinous blood are of 

 a similar shape and equal size, and Muller has not been 

 able to detect any difference between the globules in the 

 veins of the lungs of the frog and those of the body. He 

 examined the effect of oxygen and carbonic acids upon the 

 blood, in a tube over mercury. The former changed the 

 blood of the frog to a brighter red, the latter made it very 

 dark, and of a dirty violet colour. 



* Raspail states that hydro-chloric acid completely dissolves the glohules. 

 Ammonia and concentrated acetic acid have the same effect. Heat and alcohol 

 coagulate them. If his observations are correct, although they are at variance 

 with those of Muller, the globules must obviously consist of albumen. He affirms 

 that blood may be simulated by the spontaneous evaporation of a menstruum 

 containing albumen in solution and the addition of colouring matter. Nouveau 

 Systeme de Chimie Organique, 8vo. 1833, p. 370. — Edit. 



