Minute Anatomy of Animals. — No. III. 169 



In some of my earlier observations these two varieties of 

 globules were doubtless confounded ; and their similarity is 

 often so close, that it may well be questioned whether there 

 js any essential difference between them in many cases, al- 

 though it is difficult to avoid attributing to the effects of dis- 

 ease the unusual abundance of pus-like globules in the blood of 

 patients labouring under numerous inflammatory distempers. 



But it often happens that the pale globules appearing in 

 diseased blood are manifestly different from those found in the 

 blood during health. The former are generally rather larger, 

 more irregular in size and form, and not uncommonly more 

 opake than the latter. The globules occurring in disease too 

 often appear to be tinged, especially when examined by lamp- 

 light, of a red colour, like the blood-corpuscles described by 

 Dr. Barry as in progress of change into pus-globules. 



Case 1 . — A mare, aged 1 9, was lame of the hind-leg, which 

 in three days became prodigiously swoln ; there were many 

 purulent deposits beneath the integuments, and she had much 

 fever. Some blood, from the facial vein, was now examined, 

 and found to contain an unusual number of pus-like globules, 

 (fig. 1. A.) the average diameter of which was about 2^W*h °f 

 an English inch. They occurred for the most part singly, 

 and occasionally in clumps. When treated with dilute acetic 

 acid the globules exhibited nuclei, generally central but some- 

 times attached to the circumference ; and the smaller particles 

 or molecules (the disc-like objects of Dr. Barry), of which the 

 nuclei were composed were either closely connected together 

 or separated by minutely granular matter (fig. 1 . B.) . On the 

 fifth day, when the disease had increased, some blood from a 

 cutaneous vein of the affected limb contained about half as 

 many pus-like globules as red discs ; the former were most 

 commonly in clusters, and darker-coloured than they were 

 two days before. 



The pale globules in the blood of a healthy mare, examined 

 at the same time for comparison, were by no means so nu- 

 merous ; they were more regular in size and shape, almost all 

 between yj\,(jth and 2^Vo tn °f an ,ncn m diameter ; when sub- 

 jected to the action of dilute acetic acid they presented a nucleus', 

 the molecules of which were closely aggregated together; the 

 globules appeared rather paler than those of the diseased 

 blood, and were rarely to be seen in clumps (fig. 1. C). 



Case 2. — A gelding, aged 8, had the disease termed by 

 veterinarians laminitis, that is to say, inflammation of the vas- 

 cular laminae of the corion beneath the crust of the hoof. 

 The disease was violent; relief was attempted by abstracting 

 blood from the brachial vein, which became inflamed, and 

 the animal soon afterwards died. In the blood there was a 



