44 ON CANTHARIDES; 



Ixperiments and taken internally ; but that Ihefe effeds, with refpcdl to their 

 omhlridcs!"" »"^^"^^y' are proportionate to the age, the ftrength, and the 

 conftitution of ihe animals, and to the dofe which has been 

 adminiflered to them : That the oefophagus, the ftomach, and 

 the fmaller inteftines, are the parts which are principally af-f- 

 fedled : that ihofe animals which are not overcome by it, ex- 

 perience a defire to vomit, very conliderable pains and vari- 

 ous afTedions, which feem plainly to indicate that the parts 

 ■which have been touched by the cantharides, have a fort of 

 tendency to be diforganized. 



2d. That the aqueous extra(5l of cantharides, in fmaller 

 dofes than the infedts themfelves, produces nearly the fame 

 effeds as they do ; and alfo, that its adion on the urinary paf- 

 fages is very marked. 



3d. That the black matter is much lefs active than the ex- 

 tract; that the animals to which it has been given, are only 

 affected by gripings and vomitings, and yery rarely are killed 

 by it. 



4-thf That the green matter given internally does not appear 

 to have deleterious qualities, fince all the animals to which 

 even firong dof«s had been adminiftered, did not feera to be 

 affedled unealily by it. 



5th. Tht^t the yellow nqatter does not feem to be more ac- 

 tive than the green matter. 



6tk. That the extrad, the yellpw matter, and the black 

 matter, applied feparately to the furface of the body, occa- 

 Tioried vefication in nearly the fame fpace of time. 



^th. Th^t the green matter, applied externally, does not 

 feem to a6l when alone; but that its action is fpeedily mani- 

 fefted when it is divided by wa?:, and by that means receives 

 the confidence of a cerate. 



I rauft not omit to i^ention, that Cit. Beaupoil was not 

 fatisfied with experiraents made on animals, but had the cour 

 rage to repeat them on himfelf. It was from having obtained 

 the information he fought in this manner, that he confidered 

 himfelf intitled to conclude, that the veficating property refides 

 particularly in the extractive part and in the green part of the 

 cantharides, but that the cxtraflive part alone a6ls on the 

 urinary and genital fyftem. 



It will be obvious from the detail-; I have given, that the 

 3uthQf has carried the examination of cantharides farther than 



Thouvenelv 



