»S On the Effects of Opium 



inferior extremities, and after 10 minutes they 

 were able to draw them upwards. All the four 

 were placed in a temperature of 60 : after an 

 hour the two frogs, which had been softened 

 in a warm temperature were dead : the other 

 two were yet feeble, but were able to draw 

 their legs up to the body. After three hours 

 the animal which had been exposed to the 

 open air was more vigorous than the other. 

 Both the frogs were then put into cold water 

 at 56 degrees ; they appeared for some time to 

 have very little use of the extremities, but were 

 buoyed up near the surface ; after about half an 

 hour, both the animals had gained sufficient 

 strength to swim feebly about the water. One 

 was now removed and placed upon a dry 

 plate : after twelve hours^ the animal whicli 

 was left in the water, was dead, but the other 

 animal upon a dry plate was yet feebly alive. 



EXPERIMENT 48. 



Another frog was placed in a temperature of 

 O** : the thermometer rose immediately 8 de- 

 grees; after ten minutes thermometer at 0^ 

 The animal remained five minutes longer; 

 when taken out, it was universally rigid ; it 

 was placed in the open air, in a temperature of 



