45 On the Effects of Opi'iun 



plication of the same • substance in a smaller 

 and larger quantity, not to any difference of 

 operation in the substance itself, but as referable 

 to the condition of the organ acted upon, 

 and quantity of power acting upon it. 



SECTION 2. 



Ophun, Spirit of Wine and the Spiritus Vo- 

 latilis AromaticuSy tJirozvn into the stomach 

 of Animals. 



EXPERIMENT 2i. 



The skin was dissected from the thorax and 

 upper part of the abdomen of a frog. The 

 heart could distinctly be perceived to beat 

 through the integuments, 56 in a minute. 



Hours. MiniUes. 



11. 34. Thirty drops of a solution contain- 



ing three grains of opium, were 



thrown into the stomach ' by a 



small glass tube. 

 37. Heart beats no more than 45 : 



animal feeble. 

 42. Heart beats so feebly that it can 



scarce be numbered : 



12. — About 30 the animal convulsed : Its 



hind le^s extended. 



