BY H. G. CHAPMAN. 



527 



injections of defibrinated blood from fowls, yielded a serum nob 

 only possessed of hsemolytic power against tbe red corpuscles of 

 the fowl but also capable of giving rise, when mixed with fowl's 

 serum, to a precipitate which slowly became abundant and aggre- 

 gated into flocculi. In the same paper Bordet described " lacto- 

 sera." He applied this term to antisera which precipitated 

 caseinogen. Bordet* stated that this property of antisera had 

 already been investigated by Tchistovitch. Tchistovitchf stated 

 that, on mixing the serum of the eel with a strong antitoxin 

 from an animal (rabbit, hare, guinea-pig or dog) which had been 

 immunised for a little time, a cloud and a precipitate similar to 

 that which had been observed by M. Kraus in filtered cultures 

 of germs, were obtained. This precipitate was insoluble in water, 

 neutral salts and alkaline carbonates, but dissolved easily in 

 alkalies and acids. Its formation resembled the coagulation of 

 a substance dissolved in the toxic serum or antitoxin. 



In 1900 Ulenhuth:}; commenced his researches on the precipitins 

 with a contribution on specific tests for egg-albumens. He con- 

 cluded that, by repeated intraperitoneal administration of a solu- 

 tion of hen's egg-white into rabbits, there were formed in the serum 

 bodies which, on their addition to solutions of hen's egg-white, 

 gave rise to a cloud or precipitate; that similar results were seen 

 with solutions of pigeon's egg-white; that the serum of rabbits 

 treated with solutions of pigeon's egg-white contained bodies 

 which produce clouds and precipitates in solutions of the egg-white 

 of the fowl and pigeon; that the reaction so produced occurred 

 only with egg-white, not with the numerous other proteins tested, 

 and that the reaction showed great delicacy. In a later paper§ 

 Uhlenhuth concluded that it would not be possible to differen- 

 tiate eggs as had been possible for bloods. Gengou|| found that 

 he was unable to observe an}'^ difference in the action of hen's 



* Ann. de I'inst. i'a.-,leur, xiii., p.285, 1S99. 



+ Ann. de I'lnst. Pasteur, xiii., p. 406, 1899. 



JDeulsch. med. Wochenschr. xxvi., S.7;54, 1900. 



§ Ihid. xxvii., 8.260, 1901. 



Ann. de I'Inst. Pasteur, xvi., p. 734, 1902. 



