80 SANGUINARIA CANADENSIS. 
‘When given in smaller doses, such as produce 
nausea without vomiting, and repeated at fre- 
quent intervals, it lessens the frequency of the 
pulse in a manner somewhat analogous to the op- 
eration of Digitalis. This however is a seconda- 
ry effect, since in its primary operation it seems 
to accelerate the circulation. Exhibited in: this 
manner, it has been found useful in several 
diseases. 
In still smaller doses, or such as do not excite 
nausea, it has acquired some reputation as a tonic 
stimulant. i 
Professor Smith of Hanover, New Hampshire, 
in a paper on this plant, published in the London 
Medical Transactions, vol. i. states that he found 
the powder to operate violently as an emetic, pro- 
ducing great prostration of strength, during its 
operation, which continued for some time. He had 
not known it to act as acathartic. Snuffed up the 
nostrils, it proved sternutatory, and left a sensa- 
tion of heat for some time. Applied to fungous 
flesh it proved escharotic, and several polypi of the 
soft kind were cured by it in his hands. He found 
it of great use in th¢dmeipient stages of pulmona- 
ry consumption, given.in as large doses as the 
stomach would bear, and repeated. In cases of 
great irritation it was combined with opium. Some 
