AMERICAN HELLEBORE. 129 
and of dizziness‘at the time and for a short time’ 
after—still these effects were ‘not commen nor ex. 
cessive, 9" eonob nasitr AND, 2 Yor aldiviohs 
“+ As to its iddowenidat nailaineiiodie diseased 
states of the system; there were few opportuni: 
ties of administering it where any considerable de= 
rangement existed. In’ those’ cases which did ‘oc- 
cur it did w not! — tor We’ inferior to the common’ 
emetices. pve} eentit jo~eveob 6th, “ter 
oo The saipewal “operation dia watiseett tobe 
mucly ineréased by the inerease’ of thé’ dose’ of the’ 
medicine. Doses of six grains appeared, wheti 
they took eflect, to’ prodace vomititig #8 thorough 
and complete, astliat which followed from’ larger 
doses ; except:that the larger were perhaps more 
speédyin operating. «1 could’ find no ‘cause! for 
the failure’of so’ many of those cases ‘in which the’ 
dose amounted to six or eieht’ erains, except ‘an 
insensibility in the patient to the''stimulus of the 
medicine ; ‘and:this was rendered more probable 
from the-eireumstance that generally in those in- 
stances, the substance failed in producing any ef 
feet whatever; nausea did not often occur when 
vomiting was not-to follow it, and in no. instanee’ 
was it very clear: that:purging was produced. © > 
“Indeed this appeared to be rather a singular’ 
cirenmstance relating ‘to this substance, and one 
17 
