222 REPORTS ON INVESTIGATIONS AND PROJECTS. 



In connection with the study of nose-breathing vs. mouth-breathing, a 

 modified form of the Tissot glass nosepiece has been constructed. In study- 

 ing the different types of respiration, a lead mask with a molding material 

 on the edge of it has also been used. In all of these comparisons the pulse- 

 rate, the respiration-rate, the respiratory exchange, and the volume of res- 

 piration were obtained on subjects lying quietly at rest. 



Mr. Carpenter's extended experience in various laboratories and his unique 

 technical skill have made it possible for him so to compare all the methods 

 that the results are convincing and open to little, if any, criticism on the part 

 of the various investigators in this field. 



METABOLISM OF INEANTS. 



Projected alterations in the respiration apparatus whereby determinations 

 of oxygen will be secured have delayed somewhat active experimentation on 

 the metabolism of infants. A few experiments have been made during the 

 past year, and in the fall the research will be continued. The striking re- 

 lationship between pulse-rate and the gross metabolism was evident in in- 

 fants but a few weeks old. 



INFLUENCE OF THE HYPOPHYSEAL SECRETION UPON THE SUGAR TOLERANCE 



OF ANIMALS. 



Basing his research upon the important observations of Goetsch, Cushing, 

 and Jacobson, Dr. Homans has begun a preliminary series of experiments 

 on animals, studying the effect of the hypophyseal secretion upon the sugar 

 tolerance. These experiments, which were proceeding in a most satisfactory 

 manner, were interrupted by Dr. Homans's tour in Europe. 



INFLUENCE OF DECREASED ABSORPTION ON THE METABOLISM FOLLOWING 



INGESTION OF FOOD. 



The interesting observations made in connection with Dr. Joseph H. Pratt 

 on dogs with disturbed pancreatic secretion which exhibited a markedly dif- 

 ferent reaction to the ingestion of protein have been supplemented by a series 

 of observations on two other dogs. The research was necessarily inter- 

 rupted while the apparatus for determining oxygen with animals was being 

 developed. 



INFLUENCE OF THE INGESTION OF FOOD ON METABOLISM. 



For many years evidence has been accumulating in this laboratory with 

 regard to the influence of the ingestion of food upon metabolism. Many of 

 these experiments were made with the respiration calorimeter in Wesleyan 

 University, Middletown, Connecticut, and they have a certain fundamental 

 significance. Later investigations, however, have shown that more sharply 

 defined results can be obtained by means of the newly devised respiration 

 apparatus, and hence the earlier work is being in part repeated and verified 

 with this apparatus. The greater part of the work has been completed and 



