NUTRITION LABORATORY. 229 



opportunity to study the relationship between the severity of the diabetes 

 and the degree of increased metabolism. Further evidence is supplied by a 

 study of the influence of an experimentally induced acidosis upon the 

 metabolism of a normal individual, experiments being made with two sub- 

 jects when a carbohydrate-free diet was given. 



As a result of these investigations, the conclusion is drawn that the me- 

 tabolism in diabetes is increased above the normal about 15 per cent, thus 

 confirming the conclusion given in the first report. The authors also be- 

 lieve that there is a close relation between the intensity of the metabolism 

 and the severity of the disease, this being indicated not only in the compari- 

 son of the metabolism in light cases of diabetes with that in severe cases, 

 but also in the comparison of the metabolism of the same individual with 

 varying degrees of acidosis, and by the fact that normal individuals on a 

 carbohydrate-free diet showed an increase in metabolism. 



