FRIEDRICH DANIEL VON RECKLINGHAUSEN. 873 



that the connective tissue was filled with spaces communicating with 

 lymphatics, and in which the cells lie. This work led him to the 

 study of the character of the ceils in the tissue, and in a further publica- 

 tion "Uber Eiter vmd Bindcgcwebs-korperchen" he showed the amoe- 

 boid motion of certain of the cells, and their identity with leucocytes 

 and pus cells. This work undoubtedly paved the way to the studies 

 of Cohnheim on leucocyte migration and inflammation, Cohnheim 

 being a young assistant in the laboratory. During his professorship 

 in Wurzburg a great number of important publications on pathological 

 anatomical conditions appeared, in one of which " Uber Pilzmetas- 

 tasen" he showed for the first time the relation between metastatic 

 inflammatory foci and masses of bacteria in the blood vessels. 



It was during the period in Strassburg that his wonderful activity 

 in scientific research reached its acme. There are few subjects, 

 either in general pathology or in pathological anatomy, which were 

 not advanced through his work. His various researches on the blood, 

 the heart and circulation were followed in 1883 by a large and com- 

 prehensive work "Handbuch der Ernahrung." This work, which 

 treats of the different forms of disturbances of the circulation and 

 nutrition, is based on his rich experience and his wide knowledge of 

 the literature of the subject, and remains a veritable mine of informa- 

 tion for one working on the subject. In 1881 the monograph "Uber 

 die multiplen Fibrome der Haut und ihre Beziehung zu den multiplen 

 Neuromen" appeared as a contribution in honor of Rudolf ^^irchow's 

 twenty -five year jubilee. The article is a classic, showing the relation 

 of the multiple fibromas to the nerves of the skin, and the condition 

 since then has been known as von Recklinghausen's Disease. In 

 1886 appeared in Virchow's Archives a series of articles "Untersuch- 

 ungen iiber Spinabifida" which must be reckoned among the most 

 important contributions of this painstaking and prolific author. The 

 work is based on thorough macro and microscopic investigation of a 

 large amount of material, and the subject, formerly obscure, was 

 completely cleared up. 



The peculiar tumors of the uterus and Fallopian tubes, the adeno- 

 myomata, are treated in a series of articles between 1893-99. He 

 was especially attracted to the diseases of bones which form, from the 

 complexity of the tissue and the nature of the material, one of the most 

 difficult subjects in pathology. In 1891 he published a large mono- 

 graph on "Die fibrose oder deformierender Ostitis," a condition which 

 is also known as von Recklinghausen's Disease, and this was followed 

 by a great number of articles on various forms of bone disease and 

 resulting deformities. The last great work, on the subject "Unter- 



