150 PROCEEDINGS OF THE AMERICAN ACADEMY. 



of arsenic and copper. In previous years, she had no especial trouble 

 except occasional pains in shoulder joints and back, but in the winter 

 in question these increased, and she began to lose appetite and flesh, 

 and her health was generally bad until she went away for the summer. 

 After her return in improved health, she continued well at first, but 

 came down after a while with fever, with severe pain in the neck and 

 shoulders. The latter left her with the fever, but there remained a 

 peculiar unpleasant feeling, accompanied by pain in the abdomen. 

 She was also troubled by insomnia, which, oddly enough, appeared to 

 be intermittent, a sleepless night being followed by one of compara- 

 tive rest. Her appetite was poor, but there was no marked symptom 

 of digestive disturbance, and the tongue was not coated. There was 

 dryness and burning in the throat. Constipation was marked. The 

 spleen was not enlarged. 850 c.c. of the urine, after treatment with 

 potassic chlorate and hydrochloric acid, were evaporated to 20 c.c, 

 and the solution, free from chlorine, was introduced into the Marsh 

 apparatus previously tested (time not given) for absence of arsenic. 

 After thirty minutes, a very slight mirror was obtained, which looked 

 like arsenic. The patient was then removed to another room and ten 

 grains potassic iodide given daily. After ten days, the urine was an- 

 alyzed again, and a much larger and more characteristic mirror was 

 found. The iodide was continued for some time, until the patient 

 grew better and suffered no return of the symptoms. The freedom 

 of the urine from arsenic was not then determined. 



3. A woman forty-five years old had had typhus, from which she 

 recovered very slowly, the convalescence being retarded by certain 

 symptoms which were inexplicable. She had no appetite and suffered 

 great distress before meals. The tongue was, however, clean. She 

 had pain in the head, insomnia, was irritable and peevish. Pulse 

 normal. After the patient had been nine weeks in bed and was get- 

 ting no better, the covering of the wall was analyzed, and arsenic and 

 copper were found in quantity. Fifteen grains of potassic iodide were 

 given daily, and, after some days, the urine was analyzed. The appa- 

 ratus was carefully tested and the urine residue gave a slight but un- 

 mistakable mirror which gave reactions for arsenic. The patient was 

 removed to another room and the iodide continued. The symptoms 

 began to disappear, and in four weeks the patient was entirely well. 



4. A girl twenty-four years old had typhus in the autumn of 1857, 

 from which she was recovering. Pulse was normal and tongue clear. 

 Constipation marked. Appetite did not return and patient did not 

 recover strength, but was confined to her bed most of the time. She 



