LEWIS ET AL. : GROWTH HORMONE- AND PROLACTIN-LIKE PROTEINS 



i 



of Endocrinology, Scripps Clinic and Research 

 Foundation, for the antisera used in these 

 studies, and to Ronald Dotson and John La- 

 Grange of the National Marine Fisheries Service 

 for their assistance in catching the sharks. 



ADDENDUM 



The S component of the shark pituitary gland 

 was tested for its ability to produce growth in 

 hypophysectomized Fuyidulus heteroclitiis. The 

 results are shown in Figure 7. The preparation 

 was found to be as potent as a previously as- 

 sayed sample of hake growth hormone (Wil- 

 helmi, 1955). 



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Figure 7. — Growth of two hypophysectomized male 

 Fundulus heteroclitus after administration of growth 

 hormone. Eleven weeks after hypophysectomy (HY- 

 POX), injections of hake growth hormone (HAKE GH) 

 (Wilhelmi, 1955) were begun and continued for five 

 weeks. The injections were discontinued for two weeks 

 and then resumed with shark growth hormone (SGH) 

 for a period of four weeks. The S component of the 

 shark pituitary gland was used. Both the hake and 

 shark growth hormones were injected three times weekly 

 at a dosage of 20 /ig of hormone per gram (wet weight) 

 of fish. 



LITERATURE CITED 



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