TABLE Al. 



SUMMARY OF THE INCIDENCE OF NEOPLASMS IN MALE RATS IN THE TWO-YEAR FEED 

 STUDY OF NITROFURANTOIN (Continued) 



Untreated Control 



Low Dose 



High Dose 



URINARY SYSTEM 



Kidney (50) 



Carcinoma, metastatic, Zymbal gland 

 Fibrosarcoma, metastatic, skin 



Leukemia mononuclear 4 (8%) 



Mesothelioma malignant 

 Osteosarcoma, metastatic, bone 

 Pelvis, transitional epithelium, carcinoma 

 Renal tubule, adenoma 

 Renal tubule, carcinoma 

 Urinary bladder (50) 



Leukemia mononuclear 

 Mesothelioma malignant 1 (2%) 



(50) 



1 (2%) 

 3 (6%) 

 1 (2%) 



1 (2%) 



(50) 



1 (2%) 

 1 (2%) 



(50) 



1 (2%) 



1 (2%) 



1 (2%) 



1 (2%) 



2 (4%) 

 1 (2%) 



(50) 



1 (2%) 



SYSTEMIC LESIONS 

 Multiple organs 



Leukemia mononuclear 

 Mesothelioma malignant 

 Hemangiosarcoma 

 Mesothelioma benign 

 Hemangioma 



(50) 

 15 (30%) 



1 (2%) 



2 (4%) 

 1 (2%) 



ANIMAL DISPOSITION SUMMARY 

 Animals initially in study 

 Moribund 

 Terminal sacrifice 

 Dead 



50 



24 



23 



3 



50 



22 



27 



1 



50 



21 



26 



3 



TUMOR SUMMARY 



Total animals with primary neoplasms** 49 



Total primary neoplasms 151 



Total animals with benign neoplasms 49 



Total benign neoplasms 102 



Total animals with malignant neoplasms 37 



Total malignant neoplasms 49 



Total animals with secondary neoplasms*** 2 



Total secondary neoplasms 2 



Total animals with malignant neoplasms- 

 uncertain primary site 1 

 Total animals with neoplasms- 

 uncertain benign or malignant 

 Total uncertain neoplasms 



50 



156 



47 



116 



31 



39 



2 



5 



48 



120 



40 



84 



30 



35 



2 



5 



• Number of animals receiving complete necropsy examination; all gross lesions including masses examined microscopically. 



*• Primary tumors: all tumors except secondary tumors 



•** Secondary tumors: metastatic tumors or tumors invasive into an adjacent organ 



81 



Nitrofurantoin, NTP TR 341 



