TABLE Al. SUMMARY OF THE INCIDENCE OF NEOPLASMS IN MALE RATS IN THE TWO-YEAR FEED 



STUDY OF NITROFURANTOIN (Continued) 



Untreated Control 



Low Dose 



High Dose 



INTEGUMENTARY SYSTEM (Continued) 

 Skin 



Basal cell carcinoma 



Carcinoma 



Keratoacanthoma 



Keratoacanthoma, multiple 



Papilloma squamous 



Sebaceous gland, carcinoma 



Subcutaneous tissue, basosquamous tumor benign 



Subcutaneous tissue, fibroma 



Subcutaneous tissue, fibrosarcoma 



Subcutaneous tissue, fibrosarcoma, multiple 



Subcutaneous tissue, hemangioma 



Subcutaneous tissue, hemangiosarcoma 



Subcutaneous tissue, leukemia mononuclear 



Subcutaneous tissue, neoplasm, NOS 



Subcutaneous tissue, schwannoma, NOS 



Subcutaneous tissue, sebaceous gland, adenoma 



(50) 

 3 



(6%) 



4 (8%) 



(2%) 

 (2%) 



1 (2%) 



(4%) 

 (2%) 



1 (2%) 

 1 (2%) 



1 (2%) 



1 (2%) 



MUSCULOSKELETAL SYSTEM 

 Bone 



Fibrosarcoma, metastatic, skin 

 Femur, osteosarcoma 

 Vertebra, osteosarcoma 

 Skeletal muscle 



Abdominal, mesothelioma malignant 

 Diaphragm, mesothelioma malignant 



(50) 



1 (2%) 



*(50) 



1 (2%) 

 1 (2%) 



(50) 



1 (2%) 



•(50) 



1 (2%) 



(50) 



1 (2%) 

 1 (2%) 

 •(50) 



NERVOUS SYSTEM 

 Brain 



Astrocytoma malignant 

 Leukemia mononuclear 



(50) 



1 (2%) 



(50) 



1 (2%) 



(50) 



1 (2%) 



RESPIRATORY SYSTEM 

 Lung 



Carcinoma, metastatic, skin 

 Carcinoma, metastatic, Zymbal gland 

 Fibrosarcoma, metastatic, skin 

 Leukemia mononuclear 

 Osteosarcoma, metastatic, bone 

 Bronchus, squamous cell carcinoma 

 Pleura, mediastinum, alveolar/bronchiolar 

 carcinoma, metastatic, uncertain primary 

 site 

 Nose 



Submucosa, leukemia mononuclear 



(50) 



21 (42%) 



1 (2%) 

 (50) 



1 (2%) 



1 (2%) 



(49) 



(48) 



SPECIAL SENSES SYSTEM 

 Ear 



Pinna, schwannoma malignant 

 Harderian gland 



Leukemia mononuclear 

 Zymbal gland 



Carcinoma 



•(50) 



I (2%) 

 ♦(50) 



1 (2%) 

 •(50) 



2 (4%) 



♦(50) 

 •(50) 

 •(50) 



•(50) 



•(50) 



•(50) 



1 (2%) 



Nitrofurantoin, NTP TR 341 



80 



