III. RESULTS: MICE 



FOURTEEN-DAY STUDIES 



Four of five male and 4/5 female mice that re- 

 ceived 10,000 ppm and 1/5 females that received 

 5,000 ppm nitrofurantoin died before the end of 

 the studies (Table 19). Mice that received 5,000 

 and male mice that received 10,000 ppm lost 



weight. Final mean body weights of other dosed 

 groups were similar to those of the controls. Es- 

 timated feed consumption by the groups that re- 

 ceived 10,000 ppm was notably higher than that 

 by the controls during the second week of the 

 studies. Mice that received 10,000 ppm were in- 

 active, had sunken eyes, and walked on tiptoe. 



TABLE 19. SURVIVAL. MEAN BODY WEIGHTS. AND FEED CONSUMPTION OF MICE IN THE 

 FOURTEEN-DAY FEED STUDIES OF NITROFURANTOIN 



(a) Number surviving/number initially in the group 



(b) Initial group mean body weight ± standard error of the mean. Subsequent calculations are based on those animals 

 surviving to the end of the study. 



(c) Mean body weight change of the survivors ± standard error of the mean 



(d) Grams of feed consumed per animal per day; average of daily determinations; not corrected for scatter, 

 (el Day of death: 6,6,6,15 



(f) Day of death: 12 



(g) Day of death: 6,7,8,9 



49 



Nitrofurantoin, NTP TR 341 



