I. INTRODUCTION 



Use, Production, and Exposure 

 Absorption, Metabolism, and Excretion 

 Acute Toxicity 



Cellular and Subcellular Toxicity 

 Epidemiology and Systemic Toxicity 

 Reproductive and Developmental Toxicity 

 Long-Term Toxicity and Carcinogenicity 

 Genetic Toxicology 

 Study Rationale 



15 Nitrofurantoin, NTP TR 341 



