III. RESULTS: RATS 



Preputial and Clitoral Glands: Adenomas, carci- 

 nomas, and adenomas or carcinomas (combined) 

 of the preputial gland in male rats occurred with 

 significant negative trends; none was seen in the 

 high dose group (Table 17). The incidence of 

 adenomas or carcinomas (combined) of the 



clitoral gland in low dose female rats, although 

 not significantly greater than that in the con- 

 trols (control, 5/44; low dose, 10/38, high dose, 

 4/42) (see Table 15), was greater than the high- 

 est incidence in untreated historical control fe- 

 male F344/N rats (6/49). 



TABLE 17. 



PREPUTIAL GLAND TUMORS IN MALE RATS IN THE TWO-YEAR FEED STUDY OF 



NITROFURANTOIN 



Control 



1.300 ppm 



2,500 ppm 



Adenoma 



Overall Rates 

 Adjusted Rates 

 Terminal Rates 

 Day ul'Firsl Observation 

 Lite Table Tests 

 [.DKistic Regression Tests 



Carcinoma 



Overall Rates 

 Adjusted Rates 

 Terminal Rates 

 Day of First Observation 

 Life Table Tests 

 Logistic Regression Tests 



Adenoma or Carcinoma (a) 



Overall Rates 

 Adjusted Rates 

 Terminal Rates 

 Day ol'First Observation 

 Life Table Tests 

 Logistic Regression Tests 



47 



Nitrofurantoin, NTP TR 341 



