APPENDIX A 



SUMMARY OF LESIONS IN MALE RATS IN 



THE TWO-YEAR FEED STUDY OF NITROFURANTOIN 



PAGE 



TABLE Al SUMMARY OF THE INCIDENCE OF NEOPLASMS IN MALE RATS IN THE 



TWO-YEAR FEED STUDY OF NITROFURANTOIN 



TABLE A2 INDIVIDUAL ANIMAL TUMOR PATHOLOGY OF MALE RATS IN THE TWO-YEAR 



FEED STUDY OF NITROFURANTOIN 



TABLE A3 ANALYSIS OF PRIMARY TUMORS IN MALE RATS IN THE TWO-YEAR FEED 



STUDY OF NITROFURANTOIN 



78 



82 



94 



TABLE A4a HISTORICAL INCIDENCE OF KIDNEY TUBULAR CELL TUMORS IN MALE F344/N 



RATS RECEIVING NO TREATMENT 99 



TABLE A4b HISTORICAL INCIDENCE OF SKELETAL SYSTEM TUMORS IN MALE F344/N 



RATS RECEIVING NO TREATMENT 100 



TABLE A4c HISTORICAL INCIDENCE OF SUBCUTANEOUS TISSUE TUMORS IN MALE 



F344/N RATS RECEIVING NO TREATMENT 101 



TABLE A4d HISTORICAL INCIDENCE OF TESTICULAR TUMORS IN MALE F344/N RATS 



RECEIVING NO TREATMENT 102 



TABLE A4e HISTORICAL INCIDENCE OF PREPUTIAL GLAND TUMORS IN MALE F344/N 



RATS RECEIVING NO TREATMENT 103 



TABLE A5 SUMMARY OF THE INCIDENCE OF NONNEOPLASTIC LESIONS IN MALE RATS 



IN THE TWO-YEAR FEED STUDY OF NITROFURANTOIN 104 



77 



Nitrofurantoin, NTP TR 341 



