TABLE CI. SUMMARY OF THE INCIDENCE OF NEOPLASMS IN MALE MICE IN THE TWO-YEAR 



FEED STUDY OF NITROFURANTOIN 



Untreated Control 



Low Dose 



High Dose 



Animals initially in study 



Animals removed 



Animals examined histopathologically 



50 

 50 

 50 



50 

 50 

 50 



50 

 50 

 50 



ALIMENTARY SYSTEM 

 Esophagus 



Lymphoma malignant lymphocytic 

 Intestine small, ileum 



Lymphoma malignant mixed 

 Intestine small, jejunum 



Lymphoma malignant lymphocytic 

 Liver 



Hemangiosarcoma 



Hemangiosarcoma, multiple 



Hepatocellular carcinoma 



Hepatocellular carcinoma, multiple 



Hepatocellular adenoma 



Hepatocellular adenoma, multiple 



Lymphoma malignant histiocytic 



Lymphoma malignant lymphocytic 



Lymphoma malignant mixed 

 Mesentery 



Alveolar/bronchiolar carcinoma, metastatic, 

 lung 



Lymphoma malignant histiocytic 

 Pancreas 



Alveolar/bronchiolar carcinoma, metastatic, 

 lung 

 Stomach, forestomach 



Fibrosarcoma 



Squamous cell carcinoma 



1 (2%) 

 1 (2%) 



CARDIOVASCULAR SYSTEM 

 Heart 



Lymphoma malignant lymphocytic 



(50) 



1 (2%) 



(50) 



(50) 



ENDOCRINE SYSTEM 

 Adrenal gland, cortex 



Adenoma 



Spindle cell, carcinoma 

 Adrenal gland, medulla 



Pheochromocytoma malignant 



Pheochromocytoma benign 

 Islets, pancreatic 



Adenoma 

 Thyroid gland 



Follicular cell, adenoma 



(50) 



(49) 

 2 (4%) 

 4 (8%) 



(50) 



(48) 



2 (4%) 



(49) 



1 (2%) 

 1 (2%) 



(48) 



(49) 



1 (2%) 



(47) 



(50) 



(49) 



1 (2%) 

 (50) 



(48) 



GENERAL BODY SYSTEM 

 None 



139 



Nitrofurantoin, NTP TR 341 



