TABLE Bl. 



SUMMARY OF THE INCIDENCE OF NEOPLASMS IN FEMALE RATS IN THE TWO-YEAR 

 FEED STUDY OF NITROFURANTOIN (Continued) 



Untreated Control 



Low Dose 



High Dose 



GENITAL SYSTEM 



Clitoral gland 

 Adenoma 

 Carcinoma 



Ovary 



Leukemia mononuclear 



Uterus 



Leiomyosarcoma 

 Leukemia mononuclear 

 Polyp stromal 

 Polyp stromal, multiple 

 Sarcoma stromal 

 Cervix, sarcoma stromal 

 Cervix, squamous cell carcmoma 

 Endometrium, adenoma 

 Endometrium, sarcoma stromal 



144) 



1 (2%) 



4 (9%) 



(50) 



(50) 



1 (2%) 



9 (18% 



1 (2%) 



2 (4%) 



>b) 



1 (2%) 



INTEGUMENTARY SYSTEM 

 Mammary gland 

 Adenocarcinoma 

 Adenocarcinoma, multiple 

 Fibroadenoma 

 Fibroadenoma, multiple 

 Fibrosarcoma 

 Skin 



Basal cell carcinoma 

 Keratoacanthoma 

 Papilloma squamous 

 Foot, papilloma squamous 

 Subcutaneous tissue, fibroma 

 Subcutaneous tissue, fibrosarcoma 

 Subcutaneous tissue, hemangiosarcoma 

 Subcutaneous tissue, leukemia mononuclear 

 Subcutaneous tissue, sarcoma 



(49) 



6 (12%) 



23 (47%) 



5 (10%) 



1 (2%) 

 (50) 



1 (2%) 



1 (2%) 



1 (2%) 



1 (2%) 



(50) 



4 (8%) 



1 (2%) 



16 (32%) 



10 (20%) 



(49) 



1 (2%) 



2 (4%) 

 1 (2%) 



(50) 



16 (32%) 

 15 (30%) 



(50) 



1 (2%) 

 1 (2%) 

 1 (2%) 



MUSCULOSKELETAL SYSTEM 



Skeletal muscle *(50) 



Diaphragm, sarcoma stromal, metastatic, uterus 1 



(2%) 



•(50) 



•(50) 



Nitrofurantoin, NTP TR 341 



112 



