TABLE 25. OVARIAN TUMORS IN FEMALE MICE IN THE TWO-YEAR FEED STUDY OF 



NITROFURANTOIN (a) 



(a) The statistical analyses used are discussed in Section II (Statistical Methods) and Table D3 (footnotes). 



(b)The equivalent dose in milligrams per kilograms per day is given in Section III (Body Weights, Feed Consumption, and 



Clinical Signs) and in Appendix G. 



(c) Historical incidence in NTP studies (mean): 4/1,858(0.2%) 



(d) No P value is reported because no tumors were observed in the 1 ,300-ppm and control groups. 



(e) Historical incidence in NTP studies (mean): 1/1,858 ( <0.1%) 



(f) Historical incidence of granulosa cell tumors or luteomas (combined) in NTP studies (mean): 8/1 ,858 (0.4%) 



57 



Nitrofurantoin, NTP TR 341 



