TABLE D5. SUMMARY OF THE INCIDENCE OF NONNEOPLASTIC LESIONS IN FEMALE MICE IN THE 

 TWO-YEAR FEED STUDY OF NITROFURANTOIN (Continued) 



Untreated Control 



Low Dose 



High Dose 



GENERAL BODY SYSTEM 

 None 



GENITAL SYSTEM 

 Clitoral gland 



Cyst 

 Ovary 



Abscess 



Atrophy 



Cyst 



Hemorrhage 



Inflammation, chronic 



Mineralization 

 Uterus 



Hydrometria 



Hyperplasia, cystic 



Inflammation, suppurative, acute 



(1) 



1 (100%) 

 (50) 



18 (36%) 



14 (28%) 



1 (2%) 



1 (2%) 



(50) 



2 (4%) 

 49 (98%) 

 11 (22%) 



(50) 



48 (96%) 

 10 (20%) 



1 (2%) 



2 (4%) 

 (50) 



49 (987o) 



(50) 



HEMATOPOIETIC SYSTEM 



Lymph node (50) 



Deep cervical, inflammation, suppurative, acute, 

 focal 



Iliac, hyperplasia 



Mediastinal, congestion 



Mediastinal, hyperplasia 



Renal, congestion 



Renal, hyperplasia 

 Lymph node, mandibular 



Congestion 



Hyperplasia 



Inflammation, suppurative, acute, focal 

 Lymph node, mesenteric 



Angiectasis 



Hyperplasia 

 Spleen 



Angiectasis 



Hematopoietic cell proliferation 



Hemorrhage 

 Thymus (47) 



Cyst 



Hemorrhage 1 



Mediastinum, inflammation, suppurative, acute 1 



(50) 



1 (2%) 

 (50) 



(45) 



(50) 



4 (8%) 

 1 (2%) 

 (48) 



1 (2%) 



(49) 



(45) 



(48) 



(50) 



1 (2%) 



2 (4%) 



(48) 



■2 (4%) 



(2%) 

 (2%) 



INTEGUMENTARY SYSTEM 

 Mammary gland 



Duct, cyst 

 Skin 



Alopecia 



Fibrosis 



Hemorrhage, focal 



Inflammation, granulomatous, focal 



Inflammation, suppurative, acute 



(48) 

 (50) 



I (2%) 



(48) 



3 (6%) 



(50) 



1 (2%) 

 1 (2%) 



Nitrofurantoin, NTP TR 341 



190 



